EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.2 | NO | nitric oxide-sensitive guanylate cyclase | Cavia porcellus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
4.6.1.2 | soluble | - |
Cavia porcellus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.2 | GTP | Cavia porcellus | NO is a major signaling molecule in the gastrointestinal tract, and released NO inhibits muscular contraction. The actions of NO are mediated by stimulation of NO-sensitive sGC and a subsequent increase in cGMP concentration | 3',5'-cyclic GMP + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.6.1.2 | Cavia porcellus | - |
adult female Hartley guinea pigs | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.6.1.2 | blood vessel | smooth muscle | Cavia porcellus | - |
4.6.1.2 | colon | smooth muscle, low enzyme expression | Cavia porcellus | - |
4.6.1.2 | gastrointestinal tract | smooth muscle and myenteric layer | Cavia porcellus | - |
4.6.1.2 | large intestine | - |
Cavia porcellus | - |
4.6.1.2 | additional information | analysis of sGC in gastrointestinal tissue, immunohistochemic analysis | Cavia porcellus | - |
4.6.1.2 | neuron | - |
Cavia porcellus | - |
4.6.1.2 | smooth muscle | gastrointestinal tract, muscularis mucosae and vasculature | Cavia porcellus | - |
4.6.1.2 | stomach | smooth muscle, low enzyme expression | Cavia porcellus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.2 | GTP | - |
Cavia porcellus | 3',5'-cyclic GMP + diphosphate | - |
? | |
4.6.1.2 | GTP | NO is a major signaling molecule in the gastrointestinal tract, and released NO inhibits muscular contraction. The actions of NO are mediated by stimulation of NO-sensitive sGC and a subsequent increase in cGMP concentration | Cavia porcellus | 3',5'-cyclic GMP + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.6.1.2 | nitric oxide-sensitive guanylate cyclase | - |
Cavia porcellus |
4.6.1.2 | NO-sensitive GC | - |
Cavia porcellus |
4.6.1.2 | sGC | - |
Cavia porcellus |
4.6.1.2 | soluble guanylate cyclase | - |
Cavia porcellus |