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Literature summary extracted from

  • Chayakulkeeree, M.; Sorrell, T.C.; Siafakas, A.R.; Wilson, C.F.; Pantarat, N.; Gerik, K.J.; Boadle, R.; Djordjevic, J.T.
    Role and mechanism of phosphatidylinositol-specific phospholipase C in survival and virulence of Cryptococcus neoformans (2008), Mol. Microbiol., 69, 809-826.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.11 additional information creation of deltaplc1 deletion mutant. Deltaplc1 fails to grow at 37°C and exhibits slightly slower, but similar growth at 25°C and 30°C. PLC1 is essential for high-temperature growth and melanin production. PLC1, but not PLC2, is essential for all of these phenotypes and that the absence of the Plc1 enzyme in deltaplc1 compromises activation of the PKC/MAPK pathway. PLC1 is essential for cell wall integrity Cryptococcus neoformans var. grubii
3.1.4.11 additional information creation of deltaplc2 deletion mutant. PLC2 is not essential for all phenotypes Cryptococcus neoformans var. grubii

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.11 additional information inactive analogue control (U73343) has no antifungal activity against Cryptococcus neoformans; inactive analogue control (U-73343) has no antifungal activity against Cryptococcus neoformans. Deltaplc1 is hypersusceptible to flucytosine, azoles and amphotericin B, but not to caspofungin Cryptococcus neoformans var. grubii
3.1.4.11 U-73122 PLC inhibitor, inhibits growth of Cryptococcus neoformans; PLC inhibitor, inhibits growth of Cryptococcus neoformans Cryptococcus neoformans var. grubii

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Cryptococcus neoformans var. grubii B4XX94
-
-
3.1.4.11 Cryptococcus neoformans var. grubii B4XX95
-
-

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 phosphatidylinositol-specific phospholipase C
-
 Cryptococcus neoformans var. grubii
3.1.4.11 PI-PLC
-
 Cryptococcus neoformans var. grubii
3.1.4.11 PLC1
-
 Cryptococcus neoformans var. grubii
3.1.4.11 PLC2
-
 Cryptococcus neoformans var. grubii