Literature summary extracted from

Ziegler, R.J.; Brown, C.; Barbon, C.M.; DAngona, A.M.; Schuchman, E.H.; Andrews, L.; Thurberg, B.L.; McPherson, J.M.; Karey, K.P.; Cheng, S.H.
Pulmonary delivery of recombinant acid sphingomyelinase improves clearance of lysosomal sphingomyelin from the lungs of a murine model of Niemann-Pick disease (2009), Mol. Genet. Metab., 97, 35-42.

Application

EC Number	Application	Comment	Organism
3.1.4.12	medicine	systemic administration of recombinant acid sphingomyelinase (rhASM) into ASM deficient mice by intranasal instillation results in hydrolysis of the abnormal storage of sphingomyelin in lysosomes of the liver, spleen and lung, pulmonary administration of rhASM may represent an alternative route of delivery to address the visceral pathology associated with ASM deficiency	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.12	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.4.12	sphingomyelin + H2O	-	Homo sapiens	N-acylsphingosine + choline phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.4.12	acid sphingomyelinase	-	Homo sapiens
3.1.4.12	ASM	-	Homo sapiens

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Release 2023.1 (January 2023)