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Literature summary extracted from

  • Chang, Y.C.; Lin, S.Y.; Liang, S.Y.; Pan, K.T.; Chou, C.C.; Chen, C.H.; Liao, C.L.; Khoo, K.H.; Meng, T.C.
    Tyrosine phosphoproteomics and identification of substrates of protein tyrosine phosphatase dPTP61F in Drosophila S2 cells by mass spectrometry-based substrate trapping strategy (2008), J. Proteome Res., 7, 1055-1066.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.48 expressed in Escherichia coli BL21 DE3 cells Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.48 C237S catalytically dead mutant Drosophila melanogaster
3.1.3.48 D203A substrate-trapping mutant Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.48 membrane
-
 Drosophila melanogaster 16020
-
3.1.3.48 nucleus
-
 Drosophila melanogaster 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.48 61000
-
 nucleus-localized enzyme form, calculated from amino acid sequence Drosophila melanogaster
3.1.3.48 62100
-
 membrane-localized enzyme form, calculated from amino acid sequence Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.48 Ni-NTA Sepharose column chromatography Drosophila melanogaster

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 S2 cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 phosphorylated Abelson interacting protein + H2O
-
 Drosophila melanogaster Abelson interacting protein + phosphate
-
 ?
3.1.3.48 phosphorylated Abl tyrosine kinase + H2O
-
 Drosophila melanogaster Abl tyrosine kinase + phosphate
-
 ?
3.1.3.48 phosphorylated Ack protein + H2O
-
 Drosophila melanogaster Ack protein + phosphate
-
 ?
3.1.3.48 phosphorylated Down syndrome cell adhesion molecule + H2O
-
 Drosophila melanogaster Down syndrome cell adhesion molecule + phosphate
-
 ?
3.1.3.48 phosphorylated eukaryotic-initiation-factor-4G + H2O
-
 Drosophila melanogaster eukaryotic-initiation-factor-4G + phosphate
-
 ?
3.1.3.48 phosphorylated fragile X related + H2O
-
 Drosophila melanogaster fragile X related + phosphate
-
 ?
3.1.3.48 phosphorylated HEM protein + H2O
-
 Drosophila melanogaster HEM protein + phosphate
-
 ?
3.1.3.48 phosphorylated hepatocyte growth factor regulated tyrosine kinase substrate + H2O
-
 Drosophila melanogaster hepatocyte growth factor regulated tyrosine kinase substrate + phosphate
-
 ?
3.1.3.48 phosphorylated Hsc-70-4 + H2O
-
 Drosophila melanogaster Hsc-70-4 + phosphate
-
 ?
3.1.3.48 phosphorylated IGF-II mRNA-binding protein + H2O
-
 Drosophila melanogaster IGF-II mRNA-binding protein + phosphate
-
 ?
3.1.3.48 phosphorylated Lasp protein + H2O
-
 Drosophila melanogaster Lasp protein + phosphate
-
 ?
3.1.3.48 phosphorylated PDGF- and VEGF-receptor related + H2O
-
 Drosophila melanogaster PDGF- and VEGF-receptor related + phosphate
-
 ?
3.1.3.48 phosphorylated poly(A)-binding protein + H2O
-
 Drosophila melanogaster poly(A)-binding protein + phosphate
-
 ?
3.1.3.48 phosphorylated polychaetoid + H2O
-
 Drosophila melanogaster polychaetoid + phosphate
-
 ?
3.1.3.48 phosphorylated rasputin + H2O
-
 Drosophila melanogaster rasputin + phosphate
-
 ?
3.1.3.48 phosphorylated RhoGAP15B + H2O
-
 Drosophila melanogaster RhoGAP15B + phosphate
-
 ?
3.1.3.48 phosphorylated SCAR + H2O
-
 Drosophila melanogaster SCAR + phosphate
-
 ?
3.1.3.48 phosphorylated SH3PX1 + H2O
-
 Drosophila melanogaster SH3PX1 + phosphate
-
 ?
3.1.3.48 phosphorylated specifically Rac1-associated protein 1 + H2O
-
 Drosophila melanogaster specifically Rac1-associated protein 1 + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 dPTP61F dPTP61F plays a central role in counteracting PTK-mediated signaling pathways as well as in regulating actin reorganization and remodeling through tyrosine dephosphorylation of critical substrates in Drosophila Drosophila melanogaster
3.1.3.48 protein tyrosine phosphatase
-
 Drosophila melanogaster
3.1.3.48 PTK
-
 Drosophila melanogaster
3.1.3.48 PTP
-
 Drosophila melanogaster