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Literature summary extracted from

  • Picao, R.C.; Andrade, S.S.; Nicoletti, A.G.; Campana, E.H.; Moraes, G.C.; Mendes, R.E.; Gales, A.C.
    Metallo-beta-Lactamase detection: comparative evaluation of double-disk synergy versus combined disk tests for IMP, GIM, SIM, SPM or VIM-producing isolates (2008), J. Clin. Microbiol., 46, 2028-2037.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.5.2.6 medicine putative development of a screening of MBL producing strains by routine clinical microbiology laboratories. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures Enterobacter cloacae
3.5.2.6 medicine putative development of a screening of MBL producing strains by routine clinical microbiology laboratories. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures Pseudomonas aeruginosa
3.5.2.6 medicine putative development of a screening of MBL producing strains by routine clinical microbiology laboratories. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures Serratia marcescens
3.5.2.6 medicine putative development of a screening of MBL producing strains by routine clinical microbiology laboratories. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures Klebsiella pneumoniae
3.5.2.6 medicine putative development of a screening of MBL producing strains by routine clinical microbiology laboratories. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures. Pseudomonas putida
3.5.2.6 medicine putative development of a screening of MBL producing strains by routine clinical microbiology laborities. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures Acinetobacter sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 2-mercaptoethanol mercaptoethanol shows no growth inhibition activity on Pseudomonas aeruginosa ATCC 27583 at all tested concentrations between 7.0 and 55 mM Pseudomonas aeruginosa
3.5.2.6 EDTA EDTA, PHEN, and MET present weak bactericidal activity against Pseudomonas aeruginosa with substrate ceftazidime Pseudomonas aeruginosa
3.5.2.6 Mercaptoacetic acid mercaptoacetic acid demonstrates hydrolytic activity against imipenem but not against ceftazidime Pseudomonas aeruginosa
3.5.2.6 Mercaptopropionic acid 1.4 mM mercaptopropionic acid demonstrates hydrolytic activity against imipenem but not against ceftazidime, mercaptopropionic acid provided the best results by using imipenem as substrate Acinetobacter sp.
3.5.2.6 Mercaptopropionic acid 1.4 mM mercaptopropionic acid demonstrates hydrolytic activity against imipenem but not against ceftazidime, mercaptopropionic acid provided the best results by using imipenem as substrate Pseudomonas aeruginosa
3.5.2.6 additional information the bactericidal effect of inhibitors of MBL is not influenced by the production of the MBL variants IMP, VIM, SPM, GIM, or SIM Pseudomonas aeruginosa
3.5.2.6 Phenanthroline phenanthroline shows no growth inhibition activity on Pseudomonas aeruginosa ATCC 27583 at all tested concentrations between 1.0 and 8.0 mM Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.2.6 a beta-lactam + H2O Enterobacter cloacae
-
 a substituted beta-amino acid
-
 ?
3.5.2.6 a beta-lactam + H2O Pseudomonas aeruginosa
-
 a substituted beta-amino acid
-
 ?
3.5.2.6 a beta-lactam + H2O Pseudomonas putida
-
 a substituted beta-amino acid
-
 ?
3.5.2.6 a beta-lactam + H2O Serratia marcescens
-
 a substituted beta-amino acid
-
 ?
3.5.2.6 a beta-lactam + H2O Klebsiella pneumoniae
-
 a substituted beta-amino acid
-
 ?
3.5.2.6 a beta-lactam + H2O Acinetobacter sp.
-
 a substituted beta-amino acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Acinetobacter sp.
-
 IMP-1 producing strains A3035, A4861, A3880, A68, A4764, A4468, A129046, A695 and A696, and SIM-1 producing strain YMC 03/9/T104
-
3.5.2.6 Enterobacter cloacae
-
 VIM-1 producing strains 75-10344, ECL3 and ECL4, and IMP-1 producing strain 199
-
3.5.2.6 Klebsiella pneumoniae
-
 IMP-1 producing strains KPN1 and KPN2
-
3.5.2.6 Pseudomonas aeruginosa
-
 strain ATCC 27853, IMP-1 producing strains 131, 144, 137, 98, 128, 130, 143, 145, 183, PSA320, IMP-13 producing strain 86-10079, IMP-16 producing strain 101-4704, IMP-18 producing strains 3486 and 3489, GIM-1 producing strain 73-5671, VIM-1 producing strain 179, VIM-2 producing strain 225 and VIM-7 producing strain 07-406, SPM-1 producing strains 48-1997 A, 14, 44, 73, 75, 76, 83, 194, 196 and 197
-
3.5.2.6 Pseudomonas putida
-
 IMP-1 producing strain 48-12346A
-
3.5.2.6 Serratia marcescens
-
 IMP-1 producing strain SM319
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.2.6 cell culture
-
 Enterobacter cloacae
-
3.5.2.6 cell culture
-
 Pseudomonas aeruginosa
-
3.5.2.6 cell culture
-
 Pseudomonas putida
-
3.5.2.6 cell culture
-
 Serratia marcescens
-
3.5.2.6 cell culture
-
 Klebsiella pneumoniae
-
3.5.2.6 cell culture
-
 Acinetobacter sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 a beta-lactam + H2O
-
 Enterobacter cloacae a substituted beta-amino acid
-
 ?
3.5.2.6 a beta-lactam + H2O
-
 Pseudomonas aeruginosa a substituted beta-amino acid
-
 ?
3.5.2.6 a beta-lactam + H2O
-
 Pseudomonas putida a substituted beta-amino acid
-
 ?
3.5.2.6 a beta-lactam + H2O
-
 Serratia marcescens a substituted beta-amino acid
-
 ?
3.5.2.6 a beta-lactam + H2O
-
 Klebsiella pneumoniae a substituted beta-amino acid
-
 ?
3.5.2.6 a beta-lactam + H2O
-
 Acinetobacter sp. a substituted beta-amino acid
-
 ?
3.5.2.6 ceftazidime + H2O cephalosporin antibiotic Enterobacter cloacae (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 ceftazidime + H2O cephalosporin antibiotic Pseudomonas aeruginosa (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 ceftazidime + H2O cephalosporin antibiotic Pseudomonas putida (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 ceftazidime + H2O cephalosporin antibiotic Serratia marcescens (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 ceftazidime + H2O cephalosporin antibiotic Klebsiella pneumoniae (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 ceftazidime + H2O cephalosporin antibiotic Acinetobacter sp. (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 imipenem + H2O beta-lactam antibiotic Enterobacter cloacae (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O beta-lactam antibiotic Pseudomonas aeruginosa (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O beta-lactam antibiotic Pseudomonas putida (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O beta-lactam antibiotic Serratia marcescens (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O beta-lactam antibiotic Klebsiella pneumoniae (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O beta-lactam antibiotic Acinetobacter sp. (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 GIM-1
-
 Pseudomonas aeruginosa
3.5.2.6 IMP-1
-
 Enterobacter cloacae
3.5.2.6 IMP-1
-
 Pseudomonas aeruginosa
3.5.2.6 IMP-1
-
 Pseudomonas putida
3.5.2.6 IMP-1
-
 Serratia marcescens
3.5.2.6 IMP-1
-
 Klebsiella pneumoniae
3.5.2.6 IMP-1
-
 Acinetobacter sp.
3.5.2.6 IMP-13
-
 Pseudomonas aeruginosa
3.5.2.6 IMP-16
-
 Pseudomonas aeruginosa
3.5.2.6 IMP-18
-
 Pseudomonas aeruginosa
3.5.2.6 MBL
-
 Enterobacter cloacae
3.5.2.6 MBL
-
 Pseudomonas aeruginosa
3.5.2.6 MBL
-
 Pseudomonas putida
3.5.2.6 MBL
-
 Serratia marcescens
3.5.2.6 MBL
-
 Klebsiella pneumoniae
3.5.2.6 MBL
-
 Acinetobacter sp.
3.5.2.6 metallo-beta-lactamase
-
 Enterobacter cloacae
3.5.2.6 metallo-beta-lactamase
-
 Pseudomonas aeruginosa
3.5.2.6 metallo-beta-lactamase
-
 Pseudomonas putida
3.5.2.6 metallo-beta-lactamase
-
 Serratia marcescens
3.5.2.6 metallo-beta-lactamase
-
 Klebsiella pneumoniae
3.5.2.6 metallo-beta-lactamase
-
 Acinetobacter sp.
3.5.2.6 SIM-1
-
 Acinetobacter sp.
3.5.2.6 SPM-1
-
 Pseudomonas aeruginosa
3.5.2.6 VIM-1
-
 Enterobacter cloacae
3.5.2.6 VIM-1
-
 Pseudomonas aeruginosa
3.5.2.6 VIM-2
-
 Pseudomonas aeruginosa
3.5.2.6 VIM-7
-
 Pseudomonas aeruginosa