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Literature summary extracted from
- Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase (2003), J. Biol. Chem., 278, 20514-20525.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.5.3.13 | expression in Escherichia coli | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.5.3.13 | N8-acetylspermine | - |
Mus musculus |  |
| 1.5.3.13 | putrescine | - |
Mus musculus | |
| 1.5.3.13 | spermidine | - |
Mus musculus | |
| 1.5.3.13 | spermine | - |
Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.5.3.13 | 56101 | - |
x * 56101, holoenzyme (FAD-containig), calculated from sequence | Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.5.3.13 | Mus musculus | Q8C0L6 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.5.3.13 | recombinant enzyme | Mus musculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.3.13 | additional information | no activity with spermidine | Mus musculus | ? | - |
? | |
| 1.5.3.13 | N1,N11-bis(ethyl)-norspermine + O2 + H2O | - |
Mus musculus | ? | - |
? | |
| 1.5.3.13 | N1,N12-bis(ethyl)-spermine + O2 + H2O | - |
Mus musculus | ? | - |
? | |
| 1.5.3.13 | N1-acetylspermidine + O2 + H2O | oxidized at the carbon on the exo-side of the N4-nitrogen | Mus musculus | putrescine + 3-acetamidopropanal + H2O2 | - |
? | |
| 1.5.3.13 | N1-acetylspermine + O2 + H2O | oxidized at the carbon on the exo-side of the N4-nitrogen | Mus musculus | spermidine + 3-acetamidopropanal + H2O2 | - |
? | |
| 1.5.3.13 | spermine + O2 + H2O | poor substrate | Mus musculus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.5.3.13 | ? | x * 56101, holoenzyme (FAD-containig), calculated from sequence | Mus musculus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.5.3.13 | MPAO | - |
Mus musculus |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.5.3.13 | 0.175 | - |
spermine | pH 7.6, 30°C | Mus musculus | |
| 1.5.3.13 | 0.415 | - |
N1,N11-bis(ethyl)-norspermine | pH 7.6, 30°C | Mus musculus | |
| 1.5.3.13 | 1.93 | - |
N1,N12-bis(ethyl)-spermine | pH 7.6, 30°C | Mus musculus | |
| 1.5.3.13 | 4.53 | - |
N1-acetylspermine | pH 7.6, 30°C | Mus musculus | |
| 1.5.3.13 | 4.85 | - |
N1-acetylspermidine | pH 7.6, 30°C | Mus musculus | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.5.3.13 | FAD | 1 mol of noncovalently bound FAD/mol of enzyme | Mus musculus | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.5.3.13 | 0.07 | - |
N8-acetylspermine | - |
Mus musculus | |
| 1.5.3.13 | 0.19 | - |
spermidine | - |
Mus musculus | |
| 1.5.3.13 | 0.75 | - |
spermine | - |
Mus musculus | |
| 1.5.3.13 | 1 | - |
putrescine | - |
Mus musculus | |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 1.5.3.13 | Mus musculus | calculated from sequence | - |
4.84 |
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