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Literature summary extracted from

  • Ugidos, A.; Morales, G.; Rial, E.; Williams, H.D.; Rojo, F.
    The coordinate regulation of multiple terminal oxidases by the Pseudomonas putida ANR global regulator (2008), Environ. Microbiol., 10, 1690-1702.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.1.1.9 Production of cytochrome c oxidase deficient strains and ANR deficient strain. Pseudomonas putida

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 KCN 1 mM inhibits all terminal oxidases excepting the CIO quinol oxidase and lead to reduced NADH oxidation between 2.5- and 4fold Pseudomonas putida
7.1.1.9 additional information In cells growing exponentially under high oxygen tension (100% air saturation), the absence of ANR lead to a 20fold decrease in mRNA levels of the Cbb3-1 oxidase gene, a decrease that is 10-fold lower than that observed in cells growing exponentially in shaken flasks, and 35-fold lower than in cells entering the stationary phase. When cells are grown under limiting oxygen supply (40% air saturation), the absence of ANR lead to a over 500fold decrease in the mRNA levels of the Cbb3-1 oxidase gene; Inactivation of the Aa3 oxidase lead to a 50% reduction in N,N,N',N'-tetramethyl-1,4-benzenediamine (TMPD)-dependent oxidase activity (electron donor specific for cytochrome c-dependent oxidases). Lack of the Cbb3-2 oxidase lead to 65% reduction.; Under aerobic conditions, inactivation of transcriptional activator gene ANR lead to a significant decrease (more than 230fold) of the mRNA corresponding to the Cbb3-1 oxidase, but have little effect on the other analysed terminal oxidases Cbb3-2 and Aa3. Pseudomonas putida

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 membrane
-
 Pseudomonas putida 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.9 additional information Pseudomonas putida inactivation of the Cbb3-1 terminal oxidase in a strain containing a wild-type ANR gene lead to a 46% decrease in cytochrome b and to a 57% decrease in cytochrome c ?
-
 ?
7.1.1.9 additional information Pseudomonas putida For all mutant strains, the NADH oxidation activity of membranes obtained from aerobic exponentially growing cultures is some higher than that of the wild-type strain (in the range of 10–35% higher) ?
-
 ?
7.1.1.9 additional information Pseudomonas putida KT 2240 inactivation of the Cbb3-1 terminal oxidase in a strain containing a wild-type ANR gene lead to a 46% decrease in cytochrome b and to a 57% decrease in cytochrome c ?
-
 ?
7.1.1.9 additional information Pseudomonas putida KT 2240 For all mutant strains, the NADH oxidation activity of membranes obtained from aerobic exponentially growing cultures is some higher than that of the wild-type strain (in the range of 10–35% higher) ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Pseudomonas putida Q88RM6 Accession number of subunit 2 of Aa3 oxidase
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7.1.1.9 Pseudomonas putida KT 2240 Q88RM6 Accession number of subunit 2 of Aa3 oxidase
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 additional information inactivation of the Cbb3-1 terminal oxidase in a strain containing a wild-type ANR gene lead to a 46% decrease in cytochrome b and to a 57% decrease in cytochrome c Pseudomonas putida ?
-
 ?
7.1.1.9 additional information For all mutant strains, the NADH oxidation activity of membranes obtained from aerobic exponentially growing cultures is some higher than that of the wild-type strain (in the range of 10–35% higher) Pseudomonas putida ?
-
 ?
7.1.1.9 additional information inactivation of the Cbb3-1 terminal oxidase in a strain containing a wild-type ANR gene lead to a 46% decrease in cytochrome b and to a 57% decrease in cytochrome c Pseudomonas putida KT 2240 ?
-
 ?
7.1.1.9 additional information For all mutant strains, the NADH oxidation activity of membranes obtained from aerobic exponentially growing cultures is some higher than that of the wild-type strain (in the range of 10–35% higher) Pseudomonas putida KT 2240 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 Aa3 terminal Oxidase
-
 Pseudomonas putida
7.1.1.9 cbb3-2 oxidase
-
 Pseudomonas putida
7.1.1.9 cbb3-2 terminal oxidase
-
 Pseudomonas putida
7.1.1.9 cytochrome aa3
-
 Pseudomonas putida