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Literature summary extracted from

  • Ugidos, A.; Morales, G.; Rial, E.; Williams, H.D.; Rojo, F.
    The coordinate regulation of multiple terminal oxidases by the Pseudomonas putida ANR global regulator (2008), Environ. Microbiol., 10, 1690-1702.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.1.1.9 Production of cytochrome c oxidase deficient strains and ANR deficient strain. Pseudomonas putida

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 KCN 1 mM inhibits all terminal oxidases excepting the CIO quinol oxidase and lead to reduced NADH oxidation between 2.5- and 4fold Pseudomonas putida
7.1.1.9 additional information Inactivation of the Aa3 oxidase lead to a 50% reduction in N,N,N',N'-tetramethyl-1,4-benzenediamine (TMPD)-dependent oxidase activity (electron donor specific for cytochrome c-dependent oxidases). Lack of the Cbb3-2 oxidase lead to 65% reduction.; In cells growing exponentially under high oxygen tension (100% air saturation), the absence of ANR lead to a 20fold decrease in mRNA levels of the Cbb3-1 oxidase gene, a decrease that is 10-fold lower than that observed in cells growing exponentially in shaken flasks, and 35-fold lower than in cells entering the stationary phase. When cells are grown under limiting oxygen supply (40% air saturation), the absence of ANR lead to a over 500fold decrease in the mRNA levels of the Cbb3-1 oxidase gene; Under aerobic conditions, inactivation of transcriptional activator gene ANR lead to a significant decrease (more than 230fold) of the mRNA corresponding to the Cbb3-1 oxidase, but have little effect on the other analysed terminal oxidases Cbb3-2 and Aa3. Pseudomonas putida

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 membrane
-
 Pseudomonas putida 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.9 additional information Pseudomonas putida For all mutant strains, the NADH oxidation activity of membranes obtained from aerobic exponentially growing cultures is some higher than that of the wild-type strain (in the range of 10–35% higher) ?
-
 ?
7.1.1.9 additional information Pseudomonas putida inactivation of the Cbb3-1 terminal oxidase in a strain containing a wild-type ANR gene lead to a 46% decrease in cytochrome b and to a 57% decrease in cytochrome c ?
-
 ?
7.1.1.9 additional information Pseudomonas putida KT 2240 For all mutant strains, the NADH oxidation activity of membranes obtained from aerobic exponentially growing cultures is some higher than that of the wild-type strain (in the range of 10–35% higher) ?
-
 ?
7.1.1.9 additional information Pseudomonas putida KT 2240 inactivation of the Cbb3-1 terminal oxidase in a strain containing a wild-type ANR gene lead to a 46% decrease in cytochrome b and to a 57% decrease in cytochrome c ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Pseudomonas putida Q88RM6 Accession number of subunit 2 of Aa3 oxidase
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7.1.1.9 Pseudomonas putida KT 2240 Q88RM6 Accession number of subunit 2 of Aa3 oxidase
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 additional information For all mutant strains, the NADH oxidation activity of membranes obtained from aerobic exponentially growing cultures is some higher than that of the wild-type strain (in the range of 10–35% higher) Pseudomonas putida ?
-
 ?
7.1.1.9 additional information inactivation of the Cbb3-1 terminal oxidase in a strain containing a wild-type ANR gene lead to a 46% decrease in cytochrome b and to a 57% decrease in cytochrome c Pseudomonas putida ?
-
 ?
7.1.1.9 additional information For all mutant strains, the NADH oxidation activity of membranes obtained from aerobic exponentially growing cultures is some higher than that of the wild-type strain (in the range of 10–35% higher) Pseudomonas putida KT 2240 ?
-
 ?
7.1.1.9 additional information inactivation of the Cbb3-1 terminal oxidase in a strain containing a wild-type ANR gene lead to a 46% decrease in cytochrome b and to a 57% decrease in cytochrome c Pseudomonas putida KT 2240 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 Aa3 terminal Oxidase
-
 Pseudomonas putida
7.1.1.9 cbb3-2 oxidase
-
 Pseudomonas putida
7.1.1.9 cbb3-2 terminal oxidase
-
 Pseudomonas putida
7.1.1.9 cytochrome aa3
-
 Pseudomonas putida