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Literature summary extracted from

  • Bosveld, F.; Rana, A.; Lemstra, W.; Kampinga, H.H.; Sibon, O.C.
    Drosophila phosphopantothenoylcysteine synthetase is required for tissue morphogenesis during oogenesis (2008), BMC Res. Notes, 1, 75.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
6.3.2.5 additional information mutation in dPPCS impair female fecundity and fertility, and disrupts the organization of the somatic and germ line cells, affects F-actin organization and results in abnormal PtdIns(4,5)P2 localization. Improper cell organization coincides with aberrant localization of the membrane molecules Gurken (Grk) and Notch, whose activities are required for specification of the follicle cells that pattern the eggshell. Mutations in dPPCS also induce alterations in scutellar patterning and cause wing vein abnormalities, phenotype, detailed overview Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.5 CTP + (R)-4'-phosphopantothenate + L-cysteine Drosophila melanogaster the enzyme is required for various processes that occur during oogenesis including chorion patterning, e.g. for F-actin remodeling during cytoplasmic dumping, overview CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine Drosophila melanogaster
-
 AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.5 Drosophila melanogaster
-
-
-
6.3.2.51 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.5 oocyte
-
 Drosophila melanogaster
-
6.3.2.5 ovary
-
 Drosophila melanogaster
-
6.3.2.51 egg
-
 Drosophila melanogaster
-
6.3.2.51 oocyte
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.5 CTP + (R)-4'-phosphopantothenate + L-cysteine
-
 Drosophila melanogaster CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.5 CTP + (R)-4'-phosphopantothenate + L-cysteine the enzyme is required for various processes that occur during oogenesis including chorion patterning, e.g. for F-actin remodeling during cytoplasmic dumping, overview Drosophila melanogaster CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine
-
 Drosophila melanogaster AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.5 phosphopantothenoylcysteine synthetase
-
 Drosophila melanogaster
6.3.2.5 PPCS
-
 Drosophila melanogaster
6.3.2.51 PPCS
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
6.3.2.51 malfunction enzyme mutations disrupt female fecundity, affect egg chamber development, and also induce alterations in scutellar patterning and cause wing vein abnormalities Drosophila melanogaster
6.3.2.51 physiological function the enzyme is required for various processes that occur during oogenesis including chorion patterning Drosophila melanogaster