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Literature summary extracted from

  • Hurtado-Gomez, E.; Abian, O.; Munoz, F.J.; Hernaiz, M.J.; Velazquez-Campoy, A.; Neira, J.L.
    Defining the epitope region of a peptide from the Streptomyces coelicolor phosphoenolpyruvate:sugar phosphotransferase system able to bind to the enzyme I (2008), Biophys. J., 95, 1336-1348.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.3.9 phosphoenolpyruvate dependent on Streptomyces coelicolor

Application

EC Number Application Comment Organism
2.7.3.9 drug development the enzyme is a target for antibacterial drugs. These drugs can be obtained from peptides or protein fragments able to interfere with the first reaction of the protein cascade: the phosphorylation of the HPr by the first enzyme, the so-called enzyme enzyme I, overview Streptomyces coelicolor

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.3.9 HPr9-30 peptide i.e. Ac-GWAEGLHARPASIFVRAATATG-CONH2, derived from HPrsc, spanning residues Gly-9 to Ala-30 Streptomyces coelicolor
2.7.3.9 additional information design and development of specific drugs, which can be obtained from peptides or protein fragments able to interfere with the first reaction of the protein cascade: the phosphorylation of the HPr by the first enzyme, the so-called enzyme enzyme I, overview. Interaction and binding analysis by fluorescence and circular dichroism, thermodynamic parameters, detailed overview Streptomyces coelicolor

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.3.9 cytosol
-
 Streptomyces coelicolor 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.3.9 additional information Streptomyces coelicolor the bacterial phosphoenolpyruvate:sugar phosphotransferase system, PTS, consists of a cascade of several proteins involved in the uptake and phosphorylation of carbohydrates, and in signal transduction pathways, overview. The PTS involves a cascade of phosphoryl-transfer steps from phosphoenolpyruvate to sugar-specific enzyme II permeases via phosphointermediates of the general cytosolic non-sugar-specific phosphotransferase enzyme I and HPr ?
-
 ?
2.7.3.9 phosphoenolpyruvate + protein histidine Streptomyces coelicolor the dimeric protein enzyme I is autophosphorylated on a histidine residue by PEP, followed by phosphoryl group transfer to the histidine phosphocarrier protein, HPr, overview pyruvate + protein phospho-L-histidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.3.9 Streptomyces coelicolor Q9KZP1
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.3.9 phosphoprotein the dimeric protein enzyme I is autophosphorylated on a histidine residue by PEP, followed by phosphoryl group transfer to the histidine phosphocarrier protein, HPr, overview Streptomyces coelicolor

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.3.9 additional information the bacterial phosphoenolpyruvate:sugar phosphotransferase system, PTS, consists of a cascade of several proteins involved in the uptake and phosphorylation of carbohydrates, and in signal transduction pathways, overview. The PTS involves a cascade of phosphoryl-transfer steps from phosphoenolpyruvate to sugar-specific enzyme II permeases via phosphointermediates of the general cytosolic non-sugar-specific phosphotransferase enzyme I and HPr Streptomyces coelicolor ?
-
 ?
2.7.3.9 phosphoenolpyruvate + protein histidine the dimeric protein enzyme I is autophosphorylated on a histidine residue by PEP, followed by phosphoryl group transfer to the histidine phosphocarrier protein, HPr, overview Streptomyces coelicolor pyruvate + protein phospho-L-histidine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.3.9 non-sugar-specific phosphotransferase
-
 Streptomyces coelicolor
2.7.3.9 PEP:sugar PT
-
 Streptomyces coelicolor
2.7.3.9 phosphoenolpyruvate:sugar phosphotransferase
-
 Streptomyces coelicolor