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Literature summary extracted from

  • Takasawa, R.; Takahashi, S.; Saeki, K.; Sunaga, S.; Yoshimori, A.; Tanuma, S.
    Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects (2008), Bioorg. Med. Chem., 16, 3969-3975.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.5 baicalein 79% inhibition of rhGLO I at 0.1 mM Homo sapiens
4.4.1.5 Baicalin 30% inhibition of rhGLO I at 0.1 mM Homo sapiens
4.4.1.5 hyperin below 5% inhibition of rhGLO I at 0.1 mM Homo sapiens
4.4.1.5 kaempferol 60% inhibition of rhGLO I at 0.1 mM Homo sapiens
4.4.1.5 luteolin 90% inhibition of rhGLO I at 0.1 mM Homo sapiens
4.4.1.5 myricetin 75% inhibition of rhGLO I at 0.1 mM Homo sapiens
4.4.1.5 naringenin 50% inhibition of rhGLO I at 0.1 mM Homo sapiens
4.4.1.5 oroxylin A 140% inhibition of rhGLO I at 0.1 mM Homo sapiens
4.4.1.5 quercetin 78% inhibition of rhGLO I at 0.1 mM Homo sapiens
4.4.1.5 S-p-bromobenzylglutathione 55% inhibition of rhGLO I at 0.1 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Homo sapiens Q04760
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.5 HL-60 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 methylglyoxal + glutathione
-
 Homo sapiens S-((R)-lactoyl)glutathione determined monitoring the increase in absorbance at 240 nm for 5 min at 25°C, pH 7.0 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 GLO I
-
 Homo sapiens
4.4.1.5 glyoxalase I
-
 Homo sapiens
4.4.1.5 rhGLO I His-tagged GLO I protein Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.4.1.5 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.4.1.5 7.5
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.4.1.5 0.00056
-
 indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0 Homo sapiens myricetin
4.4.1.5 0.0032
-
 indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0 Homo sapiens quercetin
4.4.1.5 0.007
-
 indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0 Homo sapiens luteolin
4.4.1.5 0.011
-
 indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0 Homo sapiens baicalein
4.4.1.5 0.0206
-
 indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0 Homo sapiens kaempferol
4.4.1.5 0.023
-
 calculated, effectively inhibits rhGLO I at 25°C, pH 7.0 Homo sapiens S-p-bromobenzylglutathione