Literature summary extracted from

de Almeida, D.M.; Fernandes-Pedrosa, M.d.e..F.; de Andrade, R.M.; Marcelino, J.R.; Gondo-Higashi, H.; de Azevedo, I.d.e..L.; Ho, P.L.; van den Berg, C.; Tambourgi, D.V.
A new anti-loxoscelic serum produced against recombinant sphingomyelinase D: results of preclinical trials (2008), Am. J. Trop. Med. Hyg., 79, 463-470.

Application

EC Number	Application	Comment	Organism
3.1.4.41	medicine	recombinant SMase D can replace venom for anti-venom production and therapy	Loxosceles intermedia
3.1.4.41	medicine	recombinant SMase D can replace venom for anti-venom production and therapy	Loxosceles gaucho
3.1.4.41	medicine	recombinant SMase D can replace venom for anti-venom production and therapy	Loxosceles laeta

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.1.4.41	-	Loxosceles intermedia
3.1.4.41	-	Loxosceles laeta

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.1.4.41	64000	70000	SDS-PAGE	Loxosceles intermedia
3.1.4.41	64000	70000	SDS-PAGE	Loxosceles gaucho
3.1.4.41	64000	70000	SDS-PAGE	Loxosceles laeta

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.41	Loxosceles gaucho	-	-	-
3.1.4.41	Loxosceles intermedia	P0CE81	SMase D 1	-
3.1.4.41	Loxosceles intermedia	P0CE83	SMase D 2	-
3.1.4.41	Loxosceles laeta	Q8I914	SMase D 2	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.4.41	venom	-	Loxosceles intermedia	-
3.1.4.41	venom	-	Loxosceles gaucho	-
3.1.4.41	venom	-	Loxosceles laeta	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.4.41	sphingomyelin + H2O	-	Loxosceles intermedia	ceramide phosphate + choline	-	?
3.1.4.41	sphingomyelin + H2O	-	Loxosceles gaucho	ceramide phosphate + choline	-	?
3.1.4.41	sphingomyelin + H2O	-	Loxosceles laeta	ceramide phosphate + choline	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.1.4.41	homodimer	2 * 32000-35000, SDS-PAGE	Loxosceles intermedia
3.1.4.41	homodimer	2 * 32000-35000, SDS-PAGE	Loxosceles gaucho
3.1.4.41	homodimer	2 * 32000-35000, SDS-PAGE	Loxosceles laeta

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.4.41	Smase D 1	-	Loxosceles intermedia
3.1.4.41	Smase D 1	-	Loxosceles gaucho
3.1.4.41	Smase D 2	-	Loxosceles intermedia
3.1.4.41	Smase D 2	-	Loxosceles laeta
3.1.4.41	sphingomyelinase D 1	-	Loxosceles intermedia
3.1.4.41	sphingomyelinase D 1	-	Loxosceles gaucho
3.1.4.41	sphingomyelinase D 2	-	Loxosceles intermedia
3.1.4.41	sphingomyelinase D 2	-	Loxosceles laeta

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Release 2023.1 (January 2023)