Literature summary extracted from

  • Ryu, Y.B.; Westwood, I.M.; Kang, N.S.; Kim, H.Y.; Kim, J.H.; Moon, Y.H.; Park, K.H.
    Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens (2008), Phytomedicine, 15, 612-618.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.18.1 drug development kurarinol has the potential to be further developed as effective and safe anti-browning and skin-whitening agent Agaricus bisporus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 kurarinol from the root of Sophora flavescens, shows no antibacterial activity, competitive inhibitor. Is 50times more potent than lavandulylated flavanones sophoraflavanone G and kurarinone Agaricus bisporus
1.14.18.1 kurarinone from the root of Sophora flavescens, exhibits potent antibacterial activity, noncompetitive inhibitor, binds at an allosteric site Agaricus bisporus
1.14.18.1 sophoraflavanone G from the root of Sophora flavescens, exhibits potent antibacterial activity, noncompetitive inhibitor Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
Agaricus bisporus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-tyrosine + O2 + AH2
-
Agaricus bisporus L-3,4-dihydroxyphenylalanine + H2O + A
-
?
1.14.18.1 3,4-dihydroxyphenylalanine + 1/2 O2
-
Agaricus bisporus dopaquinone + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
Agaricus bisporus
1.14.18.1 monophenol, polyphenol oxidase
-
Agaricus bisporus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.18.1 37
-
enzyme assay at Agaricus bisporus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.18.1 6.5
-
enzyme assay at Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 0.0074
-
sophoraflavanone G
-
Agaricus bisporus
1.14.18.1 0.000045
-
kurarinol
-
Agaricus bisporus
1.14.18.1 0.0041
-
kurarinone
-
Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.0001
-
-
Agaricus bisporus kurarinol
1.14.18.1 0.0047
-
-
Agaricus bisporus sophoraflavanone G
1.14.18.1 0.0022
-
-
Agaricus bisporus kurarinone