Any feedback?
Literature summary extracted from
- Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens (2008), Phytomedicine, 15, 612-618.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | drug development | kurarinol has the potential to be further developed as effective and safe anti-browning and skin-whitening agent | Agaricus bisporus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.1 | kurarinol | from the root of Sophora flavescens, shows no antibacterial activity, competitive inhibitor. Is 50times more potent than lavandulylated flavanones sophoraflavanone G and kurarinone | Agaricus bisporus |  |
| 1.14.18.1 | kurarinone | from the root of Sophora flavescens, exhibits potent antibacterial activity, noncompetitive inhibitor, binds at an allosteric site | Agaricus bisporus | |
| 1.14.18.1 | sophoraflavanone G | from the root of Sophora flavescens, exhibits potent antibacterial activity, noncompetitive inhibitor | Agaricus bisporus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | Agaricus bisporus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | commercial preparation | - |
Agaricus bisporus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.1 | 3,4-dihydroxyphenylalanine + 1/2 O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? | |
| 1.14.18.1 | L-tyrosine + O2 + AH2 | - |
Agaricus bisporus | L-3,4-dihydroxyphenylalanine + H2O + A | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | monophenol, polyphenol oxidase | - |
Agaricus bisporus |
| 1.14.18.1 | tyrosinase | - |
Agaricus bisporus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | 37 | - |
enzyme assay at | Agaricus bisporus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | 6.5 | - |
enzyme assay at | Agaricus bisporus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.18.1 | 0.000045 | - |
kurarinol | - |
Agaricus bisporus | |
| 1.14.18.1 | 0.0041 | - |
kurarinone | - |
Agaricus bisporus | |
| 1.14.18.1 | 0.0074 | - |
sophoraflavanone G | - |
Agaricus bisporus | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.18.1 | 0.0001 | - |
- |
Agaricus bisporus | kurarinol | |
| 1.14.18.1 | 0.0022 | - |
- |
Agaricus bisporus | kurarinone | |
| 1.14.18.1 | 0.0047 | - |
- |
Agaricus bisporus | sophoraflavanone G | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
