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Literature summary extracted from

  • Chien, C.C.; Tsai, M.L.; Chen, C.C.; Chang, S.J.; Tseng, C.H.
    Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms (2008), Mycopathologia, 166, 117-120.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.18.1 drug development the finding that mushroom extracts contain tyrosinase activity inhibition will contribute to better understanding of how their healing properties in various Chinese traditional herbal on skin care products. Tyrosinase inhibitors are effective components of skin-lightening compounds and cosmetics Agaricus bisporus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 Antrodia camphorata extract basidiomycete, only other effect on tyrosinase activity is prepared from Antrodia camphorata using 75% ethanol extraction Agaricus bisporus
1.14.18.1 Ganoderma lucidum extract basidiomycete, also known as Lingzhi in the herbal medicine community, exhibits significant inhibition of tyrosinase activity. No difference in inhibitory effects on tyrosinase activity is observed by Ganoderma lucidum extracts obtained by the three different extraction methods (75%, 50% ethanol, and distilled water extraction) Agaricus bisporus
1.14.18.1 additional information extracts of Antrodia camphorata prepared by 50% extraction and distilled water, and all extracts prepared from Agaricus brasiliensis and Cordyceps militaris show less than 25% inhibition in the reaction mixtures contained 1 mg/ml extracts. No significant inhibitory effect on tyrosinase activity is observed when 0.1 mg/ml extracts are used in the reaction mixture Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.18.1 additional information
-
 350 Units/ml tyrosinase activity in extracts from Ganoderma lucidum, in extracts from Antrodia camphorata IC50 is about 1 mg/ml Agaricus bisporus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-tyrosine + O2 + AH2
-
 Agaricus bisporus L-dopa + H2O + A
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 additional information
-
 Ganoderma lucidum exhibits significant inhibition of tyrosinase activity, IC50 value 0.32 mg/ml Agaricus bisporus additional information