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Literature summary extracted from

  • Gao, H.; Nishida, J.; Saito, S.; Kawabata, J.
    Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase (2007), Molecules, 12, 86-97.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 6-hydroxyapigenin 5,6,7-trihydroxyflavone, high inhibitory effects on tyrosinase. Acts as a cofactor to monophenolase Agaricus bisporus
1.14.18.1 6-hydroxygalangin 5,6,7-trihydroxyflavone, high inhibitory effects on tyrosinase. Acts as a cofactor to monophenolase Agaricus bisporus
1.14.18.1 6-hydroxykaempferol 5,6,7-trihydroxyflavone, high inhibitory effects on tyrosinase. Acts as a cofactor to monophenolase. competitive inhibitor Agaricus bisporus
1.14.18.1 baicalein 5,6,7-trihydroxyflavone, high inhibitory effects on tyrosinase. Acts as a cofactor to monophenolase Agaricus bisporus
1.14.18.1 kaempferol
-
 Agaricus bisporus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.1 copper
-
 Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.18.1 3320
-
-
 Agaricus bisporus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-dopa + 1/2 O2
-
 Agaricus bisporus L-dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 0.148
-
 6-hydroxykaempferol a competitive inhibitor of tyrosinase, L-DOPA as a substrate Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.124
-
-
 Agaricus bisporus 6-hydroxykaempferol
1.14.18.1 0.182
-
-
 Agaricus bisporus 6-hydroxygalangin
1.14.18.1 0.193
-
-
 Agaricus bisporus 6-hydroxyapigenin
1.14.18.1 0.262
-
-
 Agaricus bisporus kaempferol
1.14.18.1 0.273
-
-
 Agaricus bisporus baicalein