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Literature summary extracted from

  • Siddaraju, M.N.; Dharmesh, S.M.
    Inhibition of gastric H+,K+-ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale (2007), Mol. Nutr. Food Res., 51, 324-332.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.19 4-coumaric acid
-
 Ovis aries
7.2.2.19 caffeic acid
-
 Ovis aries
7.2.2.19 Cinnamic acid
-
 Ovis aries
7.2.2.19 ferulic acid
-
 Ovis aries
7.2.2.19 gallic acid
-
 Ovis aries
7.2.2.19 gentisic acid
-
 Ovis aries
7.2.2.19 ginger hydrolysed phenolic fraction of ginger, Zingiber officinale, rhizome, constituted by cinnamic (48%), 4-coumaric (34%) and caffeic (6%) acids as major phenolic acids, as potent inhibitors of gastric cell proton potassium ATPase activity and Helicobacter pylori growth, exhibiting strong antioxidant potency, overview Ovis aries
7.2.2.19 ginger-free phenolic fraction the fraction is constituted by syringic (38%), gallic (18%) and cinnamic (14%) acids, as potent inhibitors of gastric cell proton potassium ATPase activity and Helicobacter pylori growth, exhibiting strong antioxidant potency, overview Ovis aries
7.2.2.19 lansoprazole
-
 Ovis aries
7.2.2.19 additional information determination of minimal inhibitory concentration, MIC, values Ovis aries
7.2.2.19 protocatechuic acid
-
 Ovis aries
7.2.2.19 syringic acid
-
 Ovis aries

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.19 membrane
-
 Ovis aries 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.19 Mg2+ required Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.19 ATP + H2O + H+/in + K+/out Ovis aries
-
 ADP + phosphate + H+/out + K+/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.19 Ovis aries
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.19 stomach mucosa Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.19 ATP + H2O + H+/in + K+/out
-
 Ovis aries ADP + phosphate + H+/out + K+/in
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.19 gastric H+,K+-ATPase
-
 Ovis aries

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.2.2.19 37
-
 assay at Ovis aries

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.19 6.5
-
 assay at Ovis aries

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.2.2.19 0.0015
-
 pH 6.5, 37°C Ovis aries ginger hydrolysed phenolic fraction
7.2.2.19 0.0027
-
 pH 6.5, 37°C Ovis aries caffeic acid
7.2.2.19 0.0029
-
 pH 6.5, 37°C Ovis aries ginger-free phenolic fraction
7.2.2.19 0.015
-
 pH 6.5, 37°C Ovis aries Cinnamic acid
7.2.2.19 0.0193
-
 pH 6.5, 37°C Ovis aries lansoprazole
7.2.2.19 0.034
-
 pH 6.5, 37°C Ovis aries ferulic acid
7.2.2.19 0.037
-
 pH 6.5, 37°C Ovis aries syringic acid
7.2.2.19 0.04
-
 pH 6.5, 37°C Ovis aries 4-coumaric acid
7.2.2.19 0.047
-
 pH 6.5, 37°C Ovis aries protocatechuic acid
7.2.2.19 0.059
-
 pH 6.5, 37°C Ovis aries gentisic acid
7.2.2.19 0.132
-
 pH 6.5, 37°C Ovis aries gallic acid