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Literature summary extracted from

  • Ni, Z.; Saunders, A.; Fuda, N.J.; Yao, J.; Suarez, J.R.; Webb, W.W.; Lis, J.T.
    P-TEFb is critical for the maturation of RNA polymerase II into productive elongation in vivo (2008), Mol. Cell. Biol., 28, 1161-1170.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.23 additional information enzyme inhibition affects the binding of Hsp70 to RNA polymerase II, overview Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.23 ATP + RNA polymerase II C-terminal subunit Drosophila melanogaster Positive transcription elongation factor b is the major metazoan RNA polymerase II carboxyl-terminal domain Ser2 kinase, P-TEFb is critical for the maturation of RNA PolII into productive elongation in vivo, overview ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.23 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.23 Kc cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.23 ATP + RNA polymerase II C-terminal subunit Positive transcription elongation factor b is the major metazoan RNA polymerase II carboxyl-terminal domain Ser2 kinase, P-TEFb is critical for the maturation of RNA PolII into productive elongation in vivo, overview Drosophila melanogaster ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?
2.7.11.23 ATP + RNA polymerase II C-terminal subunit phosphorylation of Ser2 Drosophila melanogaster ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.23 P-TEFb
-
 Drosophila melanogaster
2.7.11.23 Pol II CTD Ser2 kinase
-
 Drosophila melanogaster
2.7.11.23 positive transcription elongation factor b
-
 Drosophila melanogaster
2.7.11.23 RNA polymerase II carboxyl-terminal domain Ser2 kinase
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.23 ATP
-
 Drosophila melanogaster