EC Number | Cloned (Comment) | Organism |
---|---|---|
1.6.2.4 | expression in Escherichia coli | Trypanosoma cruzi |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.6.2.4 | diphenyleneiodonium | 0.03 mM, 62% inhibition; 0.03 mM, 64% inhibition; 0.03 mM, 76% inhibition | Trypanosoma cruzi |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.6.2.4 | 0.00577 | - |
NADPH | pH 7.7, 30°C | Trypanosoma cruzi | |
1.6.2.4 | 0.0098 | - |
ferricytochrome c | pH 7.7, 30°C | Trypanosoma cruzi | |
1.6.2.4 | 0.017 | - |
ferricytochrome c | pH 7.7, 30°C | Trypanosoma cruzi | |
1.6.2.4 | 0.018 | - |
ferricytochrome c | pH 7.7, 30°C | Trypanosoma cruzi | |
1.6.2.4 | 0.0511 | - |
NADPH | pH 7.7, 30°C | Trypanosoma cruzi | |
1.6.2.4 | 0.05488 | - |
NADPH | pH 7.7, 30°C | Trypanosoma cruzi |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.6.2.4 | 68600 | - |
x * 68600, calculated from sequence | Trypanosoma cruzi |
1.6.2.4 | 71300 | - |
x * 71300, calculated from sequence | Trypanosoma cruzi |
1.6.2.4 | 78400 | - |
x * 78400, calculated from sequence | Trypanosoma cruzi |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.2.4 | Trypanosoma cruzi | Q003G7 | - |
- |
1.6.2.4 | Trypanosoma cruzi | Q003G8 | - |
- |
1.6.2.4 | Trypanosoma cruzi | Q0MRD4 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.6.2.4 | - |
Trypanosoma cruzi |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.6.2.4 | amastigote | - |
Trypanosoma cruzi | - |
1.6.2.4 | epimastigote | - |
Trypanosoma cruzi | - |
1.6.2.4 | epimastigote | overexpression of TcCPR-B in Trypanosoma cruzi epimastigotes increases its resistance to the typical chemotherapeutic agents Nifurtimox and Benznidazole | Trypanosoma cruzi | - |
1.6.2.4 | additional information | presence in every Trypanosoma cruzi developmental stage | Trypanosoma cruzi | - |
1.6.2.4 | trypomastigote | - |
Trypanosoma cruzi | - |
1.6.2.4 | trypomastigote | strongly expressed | Trypanosoma cruzi | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.2.4 | 2 ferricytochrome c + NADPH | - |
Trypanosoma cruzi | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
1.6.2.4 | additional information | menadione or adrenaline are not reduced | Trypanosoma cruzi | ? | - |
? | |
1.6.2.4 | additional information | menadione or adrenaline ate not reduced | Trypanosoma cruzi | ? | - |
? | |
1.6.2.4 | NADPH + H+ + oxidized 2,6-dichlorophenolindophenol | - |
Trypanosoma cruzi | NADP+ + reduced 2,6-dichlorophenolindophenol | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.6.2.4 | ? | x * 68600, calculated from sequence | Trypanosoma cruzi |
1.6.2.4 | ? | x * 71300, calculated from sequence | Trypanosoma cruzi |
1.6.2.4 | ? | x * 78400, calculated from sequence | Trypanosoma cruzi |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.6.2.4 | CPR | - |
Trypanosoma cruzi |
1.6.2.4 | NADPH-cytochrome P450 reductase | - |
Trypanosoma cruzi |
1.6.2.4 | TcCPR-A | - |
Trypanosoma cruzi |
1.6.2.4 | TcCPR-B | - |
Trypanosoma cruzi |
1.6.2.4 | TcCPR-C | - |
Trypanosoma cruzi |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.6.2.4 | FAD | - |
Trypanosoma cruzi | |
1.6.2.4 | ferricytochrome c | - |
Trypanosoma cruzi | |
1.6.2.4 | FMN | - |
Trypanosoma cruzi | |
1.6.2.4 | NADPH | - |
Trypanosoma cruzi |