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Literature summary extracted from

  • Kim, D.S.; Lee, S.; Lee, H.K.; Park, S.H.; Ryoo, I.J.; Yoo, I.D.; Kwon, S.B.; Baek, K.J.; Na, J.I.; Park, K.C.
    The hypopigmentary action of KI-063 (a new tyrosinase inhibitor) combined with terrein (2008), J. Pharm. Pharmacol., 60, 343-348.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.18.1 drug development the suppression of tyrosinase activity by 2-butyl-5-hydroxyphenyl 3-(3,4-dihydroxyphenyl)propanoate and the inhibition of tyrosinase production by terrein appear to be an optimal combination for skin whitening Mus musculus
1.14.18.1 drug development the suppression of tyrosinase activity by 2-butyl-5-hydroxyphenyl 3-(3,4-dihydroxyphenyl)propanoate and the inhibition of tyrosinase production by terrein appear to be an optimal combination for skin whitening Agaricus bisporus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 2-butyl-5-hydroxyphenyl 3-(3,4-dihydroxyphenyl)propanoate KI-063, a new tyrosinase inhibitor, strong concentration-dependent inhibitory effect on tyrosinase activity Agaricus bisporus
1.14.18.1 2-butyl-5-hydroxyphenyl 3-(3,4-dihydroxyphenyl)propanoate KI-063 Mus musculus
1.14.18.1 terrein examine the effects of a combination of 2-butyl-5-hydroxyphenyl 3-(3,4-dihydroxyphenyl)propanoate with terrein, an agent that down-regulates microphthalmia-associated transcription factor Agaricus bisporus
1.14.18.1 terrein examines the effects of a combination of 2-butyl-5-hydroxyphenyl 3-(3,4-dihydroxyphenyl)propanoate with terrein, an agent that down-regulates microphthalmia-associated transcription factor. Cells co-treated with 2-butyl-5-hydroxyphenyl 3-(3,4-dihydroxyphenyl)propanoate and terrein show much less pigmentation than cells treated with 2-butyl-5-hydroxyphenyl 3-(3,4-dihydroxyphenyl)propanoate or terrein alone Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-
1.14.18.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-
1.14.18.1 Mel-Ab cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-dopa + 1/2 O2
-
 Mus musculus L-dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Mus musculus
1.14.18.1 tyrosinase
-
 Agaricus bisporus