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Literature summary extracted from

  • Alunni, S.; Orru, M.; Ottavi, L.
    A study on the inhibition of adenosine deaminase (2008), J. Enzyme Inhib. Med. Chem., 23, 182-189.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.4 2-Aminopurine competitive inhibition Bos taurus
3.5.4.4 4-aminopyridine competitive inhibition Bos taurus
3.5.4.4 4-aminopyrimidine competitive inhibition Bos taurus
3.5.4.4 4-hydroxypyridine competitive inhibition Bos taurus
3.5.4.4 adenine competitive inhibition Bos taurus
3.5.4.4 Inosine competitive inhibition Bos taurus
3.5.4.4 phenylhydrazine competitive inhibition Bos taurus
3.5.4.4 purine competitive inhibition Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.4 adenosine + H2O Bos taurus
-
 inosine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.4 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.4 commercial preparation from spleen Bos taurus
-
3.5.4.4 spleen
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.4 60 130 purified commercial preparation from spleen Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.4 adenosine + H2O
-
 Bos taurus inosine + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.4 ADA
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.4.4 25
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.4 7.5
-
 assay at Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.4.4 additional information
-
 additional information inhibition kinetics Bos taurus
3.5.4.4 0.17
-
 adenine pH 7.5, 25°C Bos taurus
3.5.4.4 0.25
-
 phenylhydrazine pH 7.5, 25°C Bos taurus
3.5.4.4 0.33
-
 2-Aminopurine pH 7.5, 25°C Bos taurus
3.5.4.4 0.35
-
 Inosine pH 7.5, 25°C Bos taurus
3.5.4.4 1.1
-
 purine pH 7.5, 25°C Bos taurus
3.5.4.4 1.3
-
 4-aminopyrimidine pH 7.5, 25°C Bos taurus
3.5.4.4 1.4
-
 4-hydroxypyridine pH 7.5, 25°C Bos taurus
3.5.4.4 1.8
-
 4-aminopyridine pH 7.5, 25°C Bos taurus