EC Number | Application | Comment | Organism |
---|---|---|---|
1.1.1.44 | medicine | 6-phosphogluconate dehydrogenase is a potential target for new drugs against African trypanosomiasis | Trypanosoma brucei |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.1.1.44 | - |
Trypanosoma brucei |
1.1.1.44 | crystal structures of recombinant Lactococcus lactis 6-phosphogluconate dehydrogenase in complex with substrate, cofactor, product and inhibitors | Lactococcus lactis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.44 | 4-phospho-D-erythronate | mimics the transition state of dehydrogenation. The inhibitor forces the catalytic lysine 185 into the protonated state | Trypanosoma brucei | |
1.1.1.44 | 4-phospho-D-erythronohydroxamic acid | - |
Lactococcus lactis | |
1.1.1.44 | 5-phospho-D-ribonate | substrate analogue | Trypanosoma brucei |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.44 | 0.00013 | - |
6-phospho-D-gluconate | - |
Trypanosoma brucei |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.44 | Lactococcus lactis | P96789 | - |
- |
1.1.1.44 | Trypanosoma brucei | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.44 | - |
Lactococcus lactis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.44 | 6-phospho-D-gluconate + NADP+ | - |
Trypanosoma brucei | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.44 | 6-phosphogluconate dehydrogenase | - |
Trypanosoma brucei |
1.1.1.44 | LlPDH | - |
Lactococcus lactis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.44 | 0.00013 | - |
4-phospho-D-erythronate | - |
Trypanosoma brucei | |
1.1.1.44 | 0.00095 | - |
5-phospho-D-ribonate | - |
Trypanosoma brucei |