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Literature summary extracted from

  • Jelski, W.; Zalewski, B.; Szmitkowski, M.
    The activity of class I, II, III, and IV alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer (2008), Digest. Dis. Sci., 53, 2550-2555.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.2.1.3 medicine ALDH activties are significantly higher in liver cancer cells than in normal tissue and might, therefore, be a factor of metabolic changes in low-maturity cancer cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.1 additional information Homo sapiens differences in the activities of total ADH and class I ADH isoenzyme between cancer liver tissues and healthy hepatocytes may be a factor in ethanol metabolism disorders, which can intensify carcinogenesis ?
-
 ?
1.1.1.284 formaldehyde + glutathione + NAD+ Homo sapiens the enzyme activity in increased in livers from cancer patients independent of alcohol drinking or nondrinking, with no significant differences between primary and metastatic tumors S-formylglutathione + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Homo sapiens
-
-
-
1.1.1.284 Homo sapiens
-
-
-
1.2.1.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.1 hepatoma cell
-
 Homo sapiens
-
1.1.1.1 liver most abundant in the liver Homo sapiens
-
1.1.1.284 liver from healthy individuals, cancer patients, including drinkers and nondrinkers Homo sapiens
-
1.2.1.3 hepatocyte
-
 Homo sapiens
-
1.2.1.3 liver cancer cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.284 additional information
-
 enzyme activities in livers from healthy individuals, cancer patients, including drinkers and nondrinkers, overview Homo sapiens
1.1.1.284 0.00089
-
 activity in livers from healthy persons, drinkers and nondrinkers Homo sapiens
1.1.1.284 0.0012
-
 activity in livers from cancer patients, drinkers and nondrinkers Homo sapiens
1.2.1.3 0.000119
-
 total group, n = 44, healthy tissue, mean Homo sapiens
1.2.1.3 0.00012
-
 non-drinkers, n = 25, healthy tissue, mean Homo sapiens
1.2.1.3 0.000123
-
 drinkers, n = 19, healthy tissue, mean Homo sapiens
1.2.1.3 0.000123
-
 non-drinkers, n = 25, healthy tissue, median Homo sapiens
1.2.1.3 0.000125
-
 total group, n = 44, healthy tissue, median Homo sapiens
1.2.1.3 0.000128
-
 drinkers, n = 19, healthy tissue, median Homo sapiens
1.2.1.3 0.000179
-
 metastatic tumor, mean Homo sapiens
1.2.1.3 0.000185
-
 primary tumor, mean Homo sapiens
1.2.1.3 0.000186
-
 metastatic tumor, median Homo sapiens
1.2.1.3 0.000188
-
 non-drinkers, n = 25, cancer tissue, mean Homo sapiens
1.2.1.3 0.00019
-
 non-drinkers, n = 25, cancer tissue, median Homo sapiens
1.2.1.3 0.00019
-
 total group, n = 44, cancer tissue, mean Homo sapiens
1.2.1.3 0.000192
-
 primary tumor, median Homo sapiens
1.2.1.3 0.000193
-
 total group, n = 44, cancer tissue, median Homo sapiens
1.2.1.3 0.000194
-
 drinkers, n = 19, cancer tissue, mean Homo sapiens
1.2.1.3 0.000198
-
 drinkers, n = 19, cancer tissue, median Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.1 4-methoxy-1-naphthaldehyde + NAD+ substrate for class I ADH Homo sapiens 4-methoxy-1-naphthyl alcohol + NADH + H+
-
 ?
1.1.1.1 6-methoxy-2-naphthaldehyde + NADH + H+ substrate for class II ADH Homo sapiens (6-methoxynaphthalen-2-yl)methanol + NAD+
-
 ?
1.1.1.1 benzyl alcohol + NAD+
-
 Homo sapiens benzaldehyde + NADH + H+
-
 ?
1.1.1.1 m-nitrobenzaldehyde + NAD+ substrate of class IV ADH Homo sapiens m-nitrobenzyl alcohol + NADH + H+
-
 ?
1.1.1.1 additional information differences in the activities of total ADH and class I ADH isoenzyme between cancer liver tissues and healthy hepatocytes may be a factor in ethanol metabolism disorders, which can intensify carcinogenesis Homo sapiens ?
-
 ?
1.1.1.1 n-butanol + NAD+
-
 Homo sapiens butylaldehyde + NADH + H+
-
 ?
1.1.1.284 formaldehyde + glutathione + NAD+ the enzyme activity in increased in livers from cancer patients independent of alcohol drinking or nondrinking, with no significant differences between primary and metastatic tumors Homo sapiens S-formylglutathione + NADH + H+
-
 ?
1.1.1.284 formaldehyde + glutathione + NAD+ the true substrate is S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione Homo sapiens S-formylglutathione + NADH + H+
-
 ?
1.2.1.3 6-methoxy-2-naphthaldehyde + NAD+ + H2O activity assay Homo sapiens 6-methoxy-2-naphthoate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.1 class I ADH isozyme Homo sapiens
1.1.1.1 class II ADH isozyme Homo sapiens
1.1.1.1 class IV ADH isozyme Homo sapiens
1.1.1.284 ADH III
-
 Homo sapiens
1.1.1.284 class III ADH
-
 Homo sapiens
1.1.1.284 class III alcohol dehydrogenase
-
 Homo sapiens
1.2.1.3 aldehyde dehydrogenase
-
 Homo sapiens
1.2.1.3 ALDH
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.284 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.284 8
-
 assay at Homo sapiens
1.2.1.3 8.5
-
 activity assay Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.1 NAD+
-
 Homo sapiens
1.1.1.284 NAD+
-
 Homo sapiens
1.2.1.3 NAD+
-
 Homo sapiens