Literature summary extracted from

Sim, E.; Sandy, J.; Evangelopoulos, D.; Fullam, E.; Bhakta, S.; Westwood, I.; Krylova, A.; Lack, N.; Noble, M.
Arylamine N-acetyltransferases in mycobacteria (2008), Curr. Drug Metab., 9, 510-519.

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
2.3.1.5	Mycobacterium smegmatis and Mycobacterium marinum	Mycobacterium marinum
2.3.1.5	Mycobacterium smegmatis and Mycobacterium marinum	Mycolicibacterium smegmatis

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.3.1.5	G207R	mutation found in clinically isolated strains of Mycobacterium tuberculosis, resulting in a NAT enzyme with very poor activity	Mycobacterium tuberculosis
2.3.1.5	additional information	deletion of the NAT gene results in an increased sensitivity to isoniazid by up to 3fold. Furthermore, growth of NAT deleted strains is delayed, organisms become more susceptible to antibiotics such as gentamycin and the characteristic mycobacterial cell wall lipid components are not present	Mycolicibacterium smegmatis
2.3.1.5	additional information	deletion of the NAT gene results in an increased sensitivity to isoniazid by up to 3fold. Furthermore, growth of NAT deleted strains is delayed, organisms become more susceptible to antibiotics such as gentamycin and the characteristic mycobacterial cell wall lipid components are not present. NAT gene is essential for survival of Mycobacterium bovis within macrophage	Mycobacterium tuberculosis variant bovis
2.3.1.5	additional information	overexpression in Mycobacterium bovis results in a decreased susceptibility to isoniazid in the slow growing mycobacterium	Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.3.1.5	acetyl-CoA + isoniazid	Mycolicibacterium smegmatis	-	CoA + N-acetylisoniazid	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.5	Homo sapiens	P11245	-	-
2.3.1.5	Mycobacterium avium	-	K-10, str. 104	-
2.3.1.5	Mycobacterium marinum	-	-	-
2.3.1.5	Mycobacterium sp. JLS	-	-	-
2.3.1.5	Mycobacterium sp. KMS	-	-	-
2.3.1.5	Mycobacterium sp. MCS	-	-	-
2.3.1.5	Mycobacterium tuberculosis	-	-	-
2.3.1.5	Mycobacterium tuberculosis	-	CDC1551, Haarlem, F11, C, H73Rv	-
2.3.1.5	Mycobacterium tuberculosis variant bovis	-	-	-
2.3.1.5	Mycobacterium tuberculosis variant bovis	-	BCG Pasteur, AF2122/97	-
2.3.1.5	Mycobacterium tuberculosis variant bovis BCG	-	-	-
2.3.1.5	Mycobacterium ulcerans	-	Agy99	-
2.3.1.5	Mycobacterium ulcerans Agy99	-	Agy99	-
2.3.1.5	Mycolicibacterium gilvum	-	PYR-GCK	-
2.3.1.5	Mycolicibacterium gilvum PYR-GCK	-	PYR-GCK	-
2.3.1.5	Mycolicibacterium smegmatis	O86309	-	-
2.3.1.5	Mycolicibacterium smegmatis	O86309	mc2 155	-
2.3.1.5	Mycolicibacterium vanbaalenii	-	PYR-1	-
2.3.1.5	Mycolicibacterium vanbaalenii PYR-1	-	PYR-1	-
2.3.1.5	Rhodococcus	-	RHA1	-
2.3.1.5	Rhodococcus RHA1	-	RHA1	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.1.5	acetyl-CoA + isoniazid	-	Mycolicibacterium smegmatis	CoA + N-acetylisoniazid	-	?
2.3.1.5	acetyl-CoA + isoniazid	inactivation of the anti-tubercular drug isoniazid by acetyltransfer	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.1.5	arylamine N-acetyltransferase	-	Mycobacterium avium
2.3.1.5	arylamine N-acetyltransferase	-	Mycobacterium tuberculosis
2.3.1.5	arylamine N-acetyltransferase	-	Mycobacterium tuberculosis variant bovis
2.3.1.5	arylamine N-acetyltransferase	-	Rhodococcus
2.3.1.5	arylamine N-acetyltransferase	-	Mycobacterium marinum
2.3.1.5	arylamine N-acetyltransferase	-	Mycolicibacterium vanbaalenii
2.3.1.5	arylamine N-acetyltransferase	-	Homo sapiens
2.3.1.5	arylamine N-acetyltransferase	-	Mycobacterium ulcerans
2.3.1.5	arylamine N-acetyltransferase	-	Mycobacterium sp. MCS
2.3.1.5	arylamine N-acetyltransferase	-	Mycobacterium sp. KMS
2.3.1.5	arylamine N-acetyltransferase	-	Mycobacterium sp. JLS
2.3.1.5	arylamine N-acetyltransferase	-	Mycolicibacterium gilvum
2.3.1.5	arylamine N-acetyltransferase	-	Mycobacterium tuberculosis variant bovis BCG
2.3.1.5	arylamine N-acetyltransferase	-	Mycolicibacterium smegmatis
2.3.1.5	NAT	-	Mycobacterium avium
2.3.1.5	NAT	-	Mycobacterium tuberculosis
2.3.1.5	NAT	-	Mycobacterium tuberculosis variant bovis
2.3.1.5	NAT	-	Rhodococcus
2.3.1.5	NAT	-	Mycobacterium marinum
2.3.1.5	NAT	-	Mycolicibacterium vanbaalenii
2.3.1.5	NAT	-	Homo sapiens
2.3.1.5	NAT	-	Mycobacterium ulcerans
2.3.1.5	NAT	-	Mycobacterium sp. MCS
2.3.1.5	NAT	-	Mycobacterium sp. KMS
2.3.1.5	NAT	-	Mycobacterium sp. JLS
2.3.1.5	NAT	-	Mycolicibacterium gilvum
2.3.1.5	NAT	-	Mycolicibacterium smegmatis
2.3.1.5	NAT2	-	Mycobacterium tuberculosis
2.3.1.5	NAT2	-	Mycobacterium marinum
2.3.1.5	NAT2	-	Homo sapiens
2.3.1.5	NAT2	-	Mycobacterium tuberculosis variant bovis BCG
2.3.1.5	NAT2	-	Mycolicibacterium smegmatis