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Literature summary extracted from

  • Alhamadsheh, M.M.; Musayev, F.; Komissarov, A.A.; Sachdeva, S.; Wright, H.T.; Scarsdale, N.; Florova, G.; Reynolds, K.A.
    Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes (2007), Chem. Biol., 14, 513-524.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.180 cyrstals of ecFabH and the ecFabH/methyl-CoA disulfide complex are obtained by the hanging drop method Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.180 decyl-CoA disulfide
-
 Mycobacterium tuberculosis
2.3.1.180 methyl-CoA disulfide
-
 Escherichia coli
2.3.1.180 additional information no significant inhibitory activity at 0.3 mM: butyl-CoA disulfide, sec-butyl-CoA disulfide, octyl-CoA disulfide, decyl-CoA disulfide Escherichia coli
2.3.1.180 additional information no significant inhibitory activity at 0.3 mM: methyl-CoA disulfide, butyl-CoA disulfide, sec-butyl-CoA disulfide Mycobacterium tuberculosis
2.3.1.180 octyl-CoA disulfide
-
 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.180 Escherichia coli
-
-
-
2.3.1.180 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein]
-
 Escherichia coli acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.180 ecFabH
-
 Escherichia coli
2.3.1.180 FabH
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.180 0.0012
-
-
 Mycobacterium tuberculosis decyl-CoA disulfide
2.3.1.180 0.0301
-
-
 Mycobacterium tuberculosis octyl-CoA disulfide
2.3.1.180 0.0571
-
-
 Escherichia coli methyl-CoA disulfide