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Literature summary extracted from

  • Duan, R.; Cheng, Y.; Joensson, B.A.; Ohlsson, L.; Herbst, A.; Hellstroem-Westas, L.; Nilsson, A.
    Human meconium contains significant amounts of alkaline sphingomyelinase, neutral ceramidase, and sphingolipid metabolites (2006), Pediatr. Res., 61, 61-66.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Homo sapiens the alkaline sphingomyelinase together with the neutral ceramidase catalyzes the hydrolysis of endogenous sphingomyelin and milk sphingomyelin in milk-fed infants, overview N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 intestine
-
 Homo sapiens
-
3.1.4.12 meconium first faeces of an infant Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.12 additional information
-
 activity of Alk-SMase and correlation to neutral ceramidase in meconium of different gestational ages, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?
3.1.4.12 sphingomyelin + H2O the alkaline sphingomyelinase together with the neutral ceramidase catalyzes the hydrolysis of endogenous sphingomyelin and milk sphingomyelin in milk-fed infants, overview Homo sapiens N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 alk-SMase
-
 Homo sapiens
3.1.4.12 alkaline sphingomyelinase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 9
-
 alkaline sphingomyelinase assay at Homo sapiens