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Literature summary extracted from

  • Coll, O.; Morales, A.; Fernandez-Checa, J.C.; Garcia-Ruiz, C.
    Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes (2007), J. Lipid Res., 48, 1924-1935.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information microinjection of the Bacillus cereus neutral sphingomyelinase in Xenopus laevis oocytes results in increased ceramide levels and triggered germinal vesicle breakdown and oxidant-dependent apoptosis, overview Bacillus cereus
3.1.4.12 additional information microinjection of the human acidic sphingomyelinase in Xenopus laevis oocytes results in increased ceramide levels and triggered germinal vesicle breakdown and oxidant-dependent apoptosis, overview Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.12 Mg2+ NSMase is dependent on Mg2+ Bacillus cereus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Homo sapiens exogenous acidic sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes, which can be prevented by pre-incubation of the cells with GSH-ethyl ester, overview ?
-
 ?
3.1.4.12 additional information Bacillus cereus exogenous neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes, which can be prevented by pre-incubation of the cells with GSH-ethyl ester, overview ?
-
 ?
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
 N-acylsphingosine + choline phosphate
-
 ?
3.1.4.12 sphingomyelin + H2O Bacillus cereus
-
 N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Bacillus cereus
-
-
-
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 placenta acidic SMase Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information exogenous acidic sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes, which can be prevented by pre-incubation of the cells with GSH-ethyl ester, overview Homo sapiens ?
-
 ?
3.1.4.12 additional information exogenous neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes, which can be prevented by pre-incubation of the cells with GSH-ethyl ester, overview Bacillus cereus ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Bacillus cereus N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acidic SMase
-
 Homo sapiens
3.1.4.12 aSMase
-
 Homo sapiens
3.1.4.12 bSMase
-
 Bacillus cereus
3.1.4.12 hSMase
-
 Homo sapiens
3.1.4.12 neutral sphingomyelinase
-
 Bacillus cereus
3.1.4.12 nSMase
-
 Bacillus cereus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
 assay at Homo sapiens
3.1.4.12 37
-
 assay at Bacillus cereus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 5
-
 assay at Homo sapiens
3.1.4.12 7.4
-
 assay at Bacillus cereus