EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.21.39 | mutant is expressed in Escherichia coli BL21(DE3) cells | Cavia porcellus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.21.39 | A216G | the partially humanized mutant acquires human-like P1 Phe- and angiotensin-cleaving capacity | Cavia porcellus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.39 | alpha1-Aantichymotrypsin | - |
Cavia porcellus | |
3.4.21.39 | alpha1-Aantichymotrypsin | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.39 | 0.47 | - |
Ala-Ala-Pro-Phe-4-nitroanilide | wild type enzyme | Homo sapiens | |
3.4.21.39 | 0.53 | - |
Ala-Ala-Pro-Phe-4-nitroanilide | wild type enzyme | Cavia porcellus | |
3.4.21.39 | 0.65 | - |
Ala-Ala-Pro-Phe-4-nitroanilide | mutant enzyme A216G | Cavia porcellus | |
3.4.21.39 | 0.97 | - |
Ala-Ala-Pro-Met-4-nitroanilide | wild type enzyme | Cavia porcellus | |
3.4.21.39 | 1.02 | - |
Ala-Ala-Pro-Leu-4-nitroanilide | wild type enzyme | Homo sapiens | |
3.4.21.39 | 1.5 | - |
Ala-Ala-Pro-Leu-4-nitroanilide | mutant enzyme A216G | Cavia porcellus | |
3.4.21.39 | 1.55 | - |
Ala-Ala-Pro-Leu-4-nitroanilide | wild type enzyme | Cavia porcellus | |
3.4.21.39 | 3 | - |
Ala-Ala-Pro-Met-4-nitroanilide | wild type enzyme | Homo sapiens | |
3.4.21.39 | 27 | - |
Ala-Ala-Pro-Met-4-nitroanilide | mutant enzyme A216G | Cavia porcellus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.39 | Cavia porcellus | A7WPL7 | precursor | - |
3.4.21.39 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.21.39 | Ni-NTA column chromatography and Superdex 75 gel filtration | Cavia porcellus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.39 | heart | - |
Cavia porcellus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.39 | Ala-Ala-Pro-Leu-4-nitroanilide + H2O | - |
Homo sapiens | Ala-Ala-Pro-Leu + 4-nitroaniline | - |
? | |
3.4.21.39 | Ala-Ala-Pro-Leu-4-nitroanilide + H2O | - |
Cavia porcellus | Ala-Ala-Pro-Leu + 4-nitroaniline | - |
? | |
3.4.21.39 | Ala-Ala-Pro-Met-4-nitroanilide + H2O | - |
Homo sapiens | Ala-Ala-Pro-Met + 4-nitroaniline | - |
? | |
3.4.21.39 | Ala-Ala-Pro-Met-4-nitroanilide + H2O | - |
Cavia porcellus | Ala-Ala-Pro-Met + 4-nitroaniline | - |
? | |
3.4.21.39 | Ala-Ala-Pro-Phe-4-nitroanilide + H2O | - |
Homo sapiens | Ala-Ala-Pro-Phe + 4-nitroaniline | - |
? | |
3.4.21.39 | Ala-Ala-Pro-Phe-4-nitroanilide + H2O | negligible activity | Cavia porcellus | Ala-Ala-Pro-Phe + 4-nitroaniline | - |
? | |
3.4.21.39 | angiotensin I + H2O | - |
Homo sapiens | angiotensin II + ? | - |
? | |
3.4.21.39 | additional information | lacks elastase-like preference for P1 Val or Ala, and does not cleave angiotensin I | Cavia porcellus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.39 | alpha-chymase | - |
Homo sapiens |
3.4.21.39 | alpha-chymase | - |
Cavia porcellus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.39 | 0.028 | - |
Ala-Ala-Pro-Phe-4-nitroanilide | wild type enzyme | Cavia porcellus | |
3.4.21.39 | 0.098 | - |
Ala-Ala-Pro-Met-4-nitroanilide | wild type enzyme | Cavia porcellus | |
3.4.21.39 | 0.93 | - |
Ala-Ala-Pro-Leu-4-nitroanilide | wild type enzyme | Cavia porcellus | |
3.4.21.39 | 3.9 | - |
Ala-Ala-Pro-Leu-4-nitroanilide | mutant enzyme A216G | Cavia porcellus | |
3.4.21.39 | 13 | - |
Ala-Ala-Pro-Met-4-nitroanilide | mutant enzyme A216G | Cavia porcellus | |
3.4.21.39 | 16 | - |
Ala-Ala-Pro-Phe-4-nitroanilide | mutant enzyme A216G | Cavia porcellus | |
3.4.21.39 | 19.3 | - |
Ala-Ala-Pro-Leu-4-nitroanilide | wild type enzyme | Homo sapiens | |
3.4.21.39 | 23 | - |
Ala-Ala-Pro-Met-4-nitroanilide | wild type enzyme | Homo sapiens | |
3.4.21.39 | 143 | - |
Ala-Ala-Pro-Phe-4-nitroanilide | wild type enzyme | Homo sapiens |