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Literature summary extracted from

  • Lefebvre, H.P.; Brown, S.A.; Chetboul, V.; King, J.N.; Pouchelon, J.L.; Toutain, P.L.
    Angiotensin-converting enzyme inhibitors in veterinary medicine (2007), Curr. Pharm. Des., 13, 1347-1361.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.15.1 veterinary medicine angiotensin-converting enzyme inhibitors are recommended in dogs and cats with chronic renal failure. They decrease the glomerular capillary pressure, have antiproteinuric effects, tend to delay the progression of chronic renal failure and to limit the extent of renal lesions Canis lupus familiaris
3.4.15.1 veterinary medicine angiotensin-converting enzyme inhibitors are recommended in dogs and cats with chronic renal failure. They decrease the glomerular capillary pressure, have antiproteinuric effects, tend to delay the progression of chronic renal failure and to limit the extent of renal lesions Felis catus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 benazeprilat
-
 Canis lupus familiaris
3.4.15.1 benazeprilat
-
 Felis catus
3.4.15.1 enalaprilat
-
 Canis lupus familiaris
3.4.15.1 imidaprilat
-
 Canis lupus familiaris
3.4.15.1 additional information angiotensin-converting enzyme inhibitors are recommended in dogs and cats with chronic renal failure. They decrease the glomerular capillary pressure, have antiproteinuric effects, tend to delay the progression of chronic renal failure and to limit the extent of renal lesions Canis lupus familiaris
3.4.15.1 additional information angiotensin-converting enzyme inhibitors are recommended in dogs and cats with chronic renal failure. They decrease the glomerular capillary pressure, have antiproteinuric effects, tend to delay the progression of chronic renal failure and to limit the extent of renal lesions Felis catus
3.4.15.1 ramiprilat
-
 Canis lupus familiaris

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Canis lupus familiaris
-
-
-
3.4.15.1 Felis catus
-
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.15.1 0.00000028
-
-
 Canis lupus familiaris benazeprilat
3.4.15.1 0.0000004
-
-
 Canis lupus familiaris ramiprilat
3.4.15.1 0.00000053 0.00000081
-
 Felis catus benazeprilat
3.4.15.1 0.00000109
-
-
 Canis lupus familiaris enalaprilat
3.4.15.1 0.00000278
-
-
 Canis lupus familiaris imidaprilat