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Literature summary extracted from

  • Docquier, J.D.; Riccio, M.L.; Mugnaioli, C.; Luzzaro, F.; Endimiani, A.; Toniolo, A.; Amicosante, G.; Rossolini, G.M.
    IMP-12, a new plasmid-encoded metallo-beta-lactamase from a Pseudomonas putida clinical isolate. (2003), Antimicrob. Agents Chemother., 47, 1522-1528.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.007
-
 cefuroxime
-
 Pseudomonas putida
3.5.2.6 0.0072
-
 meropenem
-
 Pseudomonas putida
3.5.2.6 0.015
-
 ceftazidime
-
 Pseudomonas putida
3.5.2.6 0.016
-
 cephalothin
-
 Pseudomonas putida
3.5.2.6 0.022
-
 cefotaxime
-
 Pseudomonas putida
3.5.2.6 0.026
-
 cefepime
-
 Pseudomonas putida
3.5.2.6 0.072
-
 nitrocefin
-
 Pseudomonas putida
3.5.2.6 0.175
-
 carbenicillin
-
 Pseudomonas putida
3.5.2.6 0.47
-
 ticarcillin
-
 Pseudomonas putida
3.5.2.6 0.92
-
 Imipenem
-
 Pseudomonas putida
3.5.2.6 1.5
-
 ampicillin
-
 Pseudomonas putida

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Pseudomonas putida Q8GIW8
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.2.6
-
 Pseudomonas putida

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 ampicillin + H2O
-
 Pseudomonas putida (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 carbenicillin + H2O
-
 Pseudomonas putida (2R,4S)-2-{(R)-carboxy[2-carboxy(phenyl)acetamido]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cefepime + H2O
-
 Pseudomonas putida (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cefotaxime + H2O
-
 Pseudomonas putida (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 ceftazidime + H2O
-
 Pseudomonas putida (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cefuroxime + H2O
-
 Pseudomonas putida (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalothin + H2O
-
 Pseudomonas putida (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O
-
 Pseudomonas putida (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 meropenem + H2O
-
 Pseudomonas putida (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Pseudomonas putida (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 ticarcillin + H2O
-
 Pseudomonas putida (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 IMP-12
-
 Pseudomonas putida
3.5.2.6 IMP-like metallo-beta-lactamase
-
 Pseudomonas putida

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.2.6 3.7
-
 carbenicillin
-
 Pseudomonas putida
3.5.2.6 6.7
-
 ceftazidime
-
 Pseudomonas putida
3.5.2.6 6.9
-
 ticarcillin
-
 Pseudomonas putida
3.5.2.6 9.5
-
 meropenem
-
 Pseudomonas putida
3.5.2.6 15
-
 cefepime
-
 Pseudomonas putida
3.5.2.6 18
-
 ampicillin
-
 Pseudomonas putida
3.5.2.6 56
-
 cefotaxime
-
 Pseudomonas putida
3.5.2.6 61
-
 cefuroxime
-
 Pseudomonas putida
3.5.2.6 118
-
 cephalothin
-
 Pseudomonas putida
3.5.2.6 240
-
 Imipenem
-
 Pseudomonas putida
3.5.2.6 570
-
 nitrocefin
-
 Pseudomonas putida

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.5.2.6 Pseudomonas putida pI-value calculated from sequence is 9.17
-
 9.2