EC Number | Cloned (Comment) | Organism |
---|---|---|
5.1.1.4 | cloned in Escherichia coli as a 6xHis-tag fusion protein | Clostridioides difficile |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
5.1.1.8 | C236S | radical loss of OH-L/D-Pro epimerization | Pseudomonas aeruginosa |
5.1.1.8 | C88S | radical loss of OH-L/D-Pro epimerization | Pseudomonas aeruginosa |
5.1.1.8 | V60F | radical loss of OH-L/D-Pro epimerization. V60 residue accounts for OH-Pro ligand specificity | Pseudomonas aeruginosa |
5.1.1.8 | V60G | almost complete loss of epimerization of trans-4-hydroxy-L-Pro, some residual activity on trans-4-hydroxy-D-Pro. V60 residue accounts for OH-Pro ligand specificity | Pseudomonas aeruginosa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.1.1.4 | pyrrole-2-carboxylic acid | - |
Clostridioides difficile |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.1.1.4 | 46.7 | - |
(25R)-3beta-hydroxycholest-5-en-27-oate | substrate: D-proline, Vmax= 0.000017 M/sec | Clostridioides difficile | |
5.1.1.4 | 60.2 | - |
(25R)-3beta-hydroxycholest-5-en-27-oate | substrate: L-proline, Vmax = 0.000027 M/sec | Clostridioides difficile | |
5.1.1.8 | 7.6 | - |
trans-4-hydroxy-L-Pro | 37°C | Brucella suis | |
5.1.1.8 | 9 | - |
trans-4-hydroxy-L-Pro | 37°C | Brucella melitensis | |
5.1.1.8 | 9.8 | - |
trans-4-hydroxy-L-Pro | 37°C | Brucella abortus | |
5.1.1.8 | 14.4 | - |
trans-4-hydroxy-L-Pro | 37°C | Burkholderia pseudomallei | |
5.1.1.8 | 14.4 | - |
trans-4-hydroxy-L-Pro | 37°C | Pseudomonas aeruginosa |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.1.1.4 | Clostridioides difficile | A8DEZ8 | - |
- |
5.1.1.4 | Clostridioides difficile VPI10463 | A8DEZ8 | - |
- |
5.1.1.8 | Brucella abortus | Q57B94 | - |
- |
5.1.1.8 | Brucella melitensis | Q8YJ29 | - |
- |
5.1.1.8 | Brucella melitensis 16M | Q8YJ29 | - |
- |
5.1.1.8 | Brucella suis | Q8FYS0 | - |
- |
5.1.1.8 | Burkholderia pseudomallei | Q63NG7 | - |
- |
5.1.1.8 | Pseudomonas aeruginosa | Q9I476 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.1.4 | L-proline | CdPRAC from Clostridium difficile racemizes both L- and D-Pro but not OH-L/D-Pro or any other natural amino acid | Clostridioides difficile | D-proline | - |
r | |
5.1.1.4 | L-proline | CdPRAC from Clostridium difficile racemizes both L- and D-Pro but not OH-L/D-Pro or any other natural amino acid | Clostridioides difficile VPI10463 | D-proline | - |
r | |
5.1.1.8 | trans-4-hydroxy-D-Pro | - |
Pseudomonas aeruginosa | cis-4-hydroxy-L-Pro | - |
? | |
5.1.1.8 | trans-4-hydroxy-L-Pro | - |
Brucella abortus | cis-4-hydroxy-D-Pro | - |
? | |
5.1.1.8 | trans-4-hydroxy-L-Pro | - |
Brucella melitensis | cis-4-hydroxy-D-Pro | - |
? | |
5.1.1.8 | trans-4-hydroxy-L-Pro | - |
Brucella suis | cis-4-hydroxy-D-Pro | - |
? | |
5.1.1.8 | trans-4-hydroxy-L-Pro | - |
Burkholderia pseudomallei | cis-4-hydroxy-D-Pro | - |
? | |
5.1.1.8 | trans-4-hydroxy-L-Pro | - |
Pseudomonas aeruginosa | cis-4-hydroxy-D-Pro | - |
? | |
5.1.1.8 | trans-4-hydroxy-L-Pro | - |
Brucella melitensis 16M | cis-4-hydroxy-D-Pro | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.1.1.4 | CdPRAC | - |
Clostridioides difficile |
5.1.1.4 | proline racemase | - |
Clostridioides difficile |
5.1.1.8 | HyPRE | - |
Brucella abortus |
5.1.1.8 | PrpA | - |
Brucella abortus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
5.1.1.4 | 37 | - |
assay at | Clostridioides difficile |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
5.1.1.4 | 6 | - |
using NaOAc | Clostridioides difficile |