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Literature summary extracted from

  • Slow, S.; Garrow, T.A.
    Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats (2006), J. Nutr., 136, 2279-2283.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.99.1 additional information the enzyme expression is not affected by methionine or choline intake in liver, overview Rattus norvegicus
2.1.1.5 choline liver BHMT activity is 1.3fold higher in rats fed the methionine deficient diet containing choline than in rats fed the methionine-adequate diet containing supplemental choline Rattus norvegicus
2.1.1.5 L-methionine independent of dietary choline, supplemental methionine increases hepatic BHMT activity by ca. 30% Rattus norvegicus
2.1.1.5 additional information choline and methionine do not affect BHMT activity, mRNA expression and immunodetectable protein in the kidney Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.99.1 additional information the enzyme expression is not affected by methionine or choline intake in liver, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.99.1 additional information Rattus norvegicus the enzyme is responsible for the two-step choline oxidation to betaine together with the betaine-homocysteine methyltransferase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.99.1 Rattus norvegicus
-
 Sprague-Dawley rats
-
2.1.1.5 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.99.1 kidney
-
 Rattus norvegicus
-
1.1.99.1 liver
-
 Rattus norvegicus
-
2.1.1.5 kidney
-
 Rattus norvegicus
-
2.1.1.5 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.99.1 additional information the enzyme is responsible for the two-step choline oxidation to betaine together with the betaine-homocysteine methyltransferase Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.99.1 CHDH
-
 Rattus norvegicus
2.1.1.5 betaine-homocysteine methyltransferase
-
 Rattus norvegicus
2.1.1.5 BHMT
-
 Rattus norvegicus