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Literature summary extracted from

  • Reddy, M.C.; Palaninathan, S.K.; Shetty, N.D.; Owen, J.L.; Watson, M.D.; Sacchettini, J.C.
    High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: Insights into the mechanism and specificity of this novel prokaryotic enzyme (2007), J. Biol. Chem., 282, 27334-27342.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.20
-
 Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.20 crystals are obtained by either hanging drop or sitting drop vapor diffusion methods. Crystal structure of of ADK unliganded as well as ligand (adenosine) bound at 1.5- and 1.9-A resolution, respectively. The structure of the binary complexes with the inhibitor 2-fluoroadenosine bound and with the adenosine 5'-(beta,gamma-methylene)triphosphate (non-hydrolyzable ATP analog) bound are solved at 1.9-A resolution Mycobacterium tuberculosis
2.7.1.20 hanging drop or sitting drop vapor diffusion methods. Crystal structure of unliganded enzyme as well as adenosine bound enzyme at 1.5 A and 1.9 A resolution, respectively. The structure of the binary complexes with the inhibitor 2-fluoroadenosine bound and with the adenosine 5'-(beta,gamma-methylene)triphosphate bound are solved at 1.9 A resolution Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.20 ATP + adenosine Mycobacterium tuberculosis
-
 ADP + AMP
-
 ?
2.7.1.20 ATP + adenosine Mycobacterium tuberculosis H37Rv
-
 ADP + AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.20 Mycobacterium tuberculosis
-
-
-
2.7.1.20 Mycobacterium tuberculosis P9WID5
-
-
2.7.1.20 Mycobacterium tuberculosis H37Rv P9WID5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.20
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.20 ATP + adenosine
-
 Mycobacterium tuberculosis ADP + AMP
-
 ?
2.7.1.20 ATP + adenosine
-
 Mycobacterium tuberculosis H37Rv ADP + AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.20 ADK
-
 Mycobacterium tuberculosis