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Literature summary extracted from

  • Knecht, W.; Rozpedowska, E.; Le Breton, C.; Willer, M.; Gojkovic, Z.; Sandrini, M.P.; Joergensen, T.; Hasholt, L.; Munch-Petersen, B.; Piskur, J.
    Drosophila deoxyribonucleoside kinase mutants with enhanced ability to phosphorylate purine analogs (2007), Gene Ther., 14, 1278-1286.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.145 medicine transduced deoxyribonucleoside kinases can be used to kill recipient cells in combination with nucleoside prodrugs Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.145 expression in Escherichia coli Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.145 additional information creation of mutants with increased specificity for several nucleoside analogs. The mutants have a reduced ability to phosphorylate pyrimidines, while the ability to phosphorylate purine analogs is relatively similar to the wild-type enzyme Drosophila melanogaster
2.7.1.145 N45D/N64D enhanced cytotoxicity for parimidine analogs especially azidothymidine Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.145 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.145
-
 Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
2.7.1.145 Dm-dNK
-
 Drosophila melanogaster