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Literature summary extracted from

  • Roll-Mecak, A.; Vale, R.D.
    The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules (2005), Curr. Biol., 15, 650-655.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.6.1.1 medicine hereditary spastic paraplegias (HSPs) are most commonly caused by mutations in the spastin gene Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.1 D-spastin-GFP for localization studies Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
5.6.1.1 D655N disease mutation Drosophila melanogaster
5.6.1.1 E542A disease mutation, Walker B motif Drosophila melanogaster
5.6.1.1 K488R disease mutation, Walker A motif Drosophila melanogaster
5.6.1.1 additional information deltaTM D-spastin-GFP: construct lacking the transmembrane-containing N-terminus, diffusely distributed in the cytoplasm, fully active for disassembling cytoplasmatic microtubules. TM+MIT: construct lacking the AAA domain, do not affect the microtubule cytoskeleton. MIT: MIT domain alone, diffusely distributed and do not disassemble microtubules. AAA: AAA domain alone, diffusely distributed and do not disassemble microtubules. Drosophila melanogaster
5.6.1.1 S462C disease mutation Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.1 cytoplasm
-
 Drosophila melanogaster 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.1 ATP + H2O Drosophila melanogaster
-
 ADP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.1 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.1 S2 cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.1 ATP + H2O
-
 Drosophila melanogaster ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.1 D-spastin Drosophila homolog of spastin Drosophila melanogaster
5.6.1.1 spastin
-
 Drosophila melanogaster

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.6.1.1 0.35
-
 ATP mutant D655N Drosophila melanogaster
5.6.1.1 1.1
-
 ATP mutant S462C Drosophila melanogaster
5.6.1.1 1.8
-
 ATP wild type, deltaTM Drosophila melanogaster