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Literature summary extracted from

  • Cambau, E.; Carthagena, L.; Chauffour, A.; Ji, B.; Jarlier, V.
    Dihydropteroate synthase mutations in the folP1 gene predict dapsone resistance in relapsed cases of leprosy (2006), Clin. Infect. Dis., 42, 238-241.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.15 additional information detection of mutations to predict dapsone resistance Mycobacterium leprae
2.5.1.15 P55A mutation associated with dapsone resistance Mycobacterium leprae
2.5.1.15 P55L mutation associated with dapsone resistance Mycobacterium leprae
2.5.1.15 T53A mutation associated with dapsone resistance Mycobacterium leprae
2.5.1.15 T53I mutation associated with dapsone resistance Mycobacterium leprae
2.5.1.15 T53V mutation associated with dapsone resistance Mycobacterium leprae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.15 dapsone
-
 Mycobacterium leprae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Mycobacterium leprae
-
 diphosphate + 7,8-dihydropteroate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Mycobacterium leprae P0C0X2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
 Mycobacterium leprae diphosphate + 7,8-dihydropteroate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.15 7,8-dihydropteroate synthase
-
 Mycobacterium leprae
2.5.1.15 DHPS
-
 Mycobacterium leprae
2.5.1.15 dihydropteroate synthetase
-
 Mycobacterium leprae
2.5.1.15 folP1
-
 Mycobacterium leprae