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Literature summary extracted from

  • Kurian, J.R.; Chin, N.A.; Longlais, B.J.; Hayes, K.L.; Trepanier, L.A.
    Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5 (2006), Chem. Res. Toxicol., 19, 1366-1373.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.6.2.2 medicine reduction of arylhydroxylamine carcinogens by enzyme and ferricytochrome b5 as a source of individual variability with respect to cancer susceptibility following exposure to arylhydroxylamines Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.2.2 0.22
-
 N-Hydroxy-4-aminobiphenyl pH 7.4 Homo sapiens
1.6.2.2 0.25
-
 N-hydroxy-2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine pH 7.4 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.2.2 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.2 ferricytochrome b5 + N-hydroxy-2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine arylhydroxylamine carcinogen found in grilled meat Homo sapiens ferrocytochrome b5 + ?
-
 ?
1.6.2.2 ferricytochrome b5 + N-hydroxy-4-aminobiphenyl arylhydroxylamine carcinogen found in cigarette smoke Homo sapiens ferrocytochrome b5 + ?
-
 ?