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Literature summary extracted from

  • Callahan, B.P.; Lomino, J.V.; Wolfenden, R.
    Nanomolar inhibition of the enterobactin biosynthesis enzyme, EntE: synthesis, substituent effects, and additivity (2006), Bioorg. Med. Chem. Lett., 16, 3802-3805.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.71 2,3-dihydroxybenzohydroxamoyl adenylate strong product analog inhibitor, competitive inhibitor Escherichia coli
6.2.1.71 2-hydroxybenzohydroxamoyl adenylate deletion of the catecholic 3-OH group of 2,3-dihydroxybenzohydroxamoyl adenylate reduces inhibitory activity by a factor of 3.5 Escherichia coli
6.2.1.71 acetohydroxamoyl adenylate replacing the entire catechol moiety of 2,3-dihydroxybenzohydroxamoyl adenylate by a hydrogen atom gives up to 10% inhibition Escherichia coli
6.2.1.71 benzohydroxamoyl adenylate deletion of both the catecholic 3-OH and 2-OH group of 2,3-dihydroxybenzohydroxamoyl adenylate reduces inhibitory activity by a factor of 2000 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.71 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.71 ATP + 2,3-dihydroxybenzoate
-
 Escherichia coli diphosphate + 2,3-dihydroxybenzoyl adenylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.71 EntE
-
 Escherichia coli
6.2.1.71 Enterobactin biosynthesis enzyme
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.2.1.71 0.000009
-
 2,3-dihydroxybenzohydroxamoyl adenylate product analog inhibitor, competitive inhibitor, result indicates that the catecholic 2-OH group is critical for tight binding Escherichia coli
6.2.1.71 0.000037
-
 2-hydroxybenzohydroxamoyl adenylate product analog inhibitor, competitive inhibitor Escherichia coli
6.2.1.71 0.013
-
 benzohydroxamoyl adenylate product analog inhibitor, competitive inhibitor Escherichia coli
6.2.1.71 1
-
 acetohydroxamoyl adenylate value above 1 Escherichia coli