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Literature summary extracted from

  • Kobayashi, M.; Watanabe, T.; Xu, Y.J.; Tatemori, M.; Goda, H.; Niitsu, M.; Shirahata, A.; Samejima, K.
    Control of spermidine and spermine levels in rat tissues by trans-4-methylcyclohexylamine, a spermidine-synthase inhibitor (2005), Biol. Pharm. Bull., 28, 569-573.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.16 trans-4-Methylcyclohexylamine in vitro and in vivo inhibition, reduces the spermidine and spermine content in rat tissue after oral application, quantification, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.16 S-adenosylmethioninamine + putrescine Rattus norvegicus
-
 5'-S-methyl-5'-thioadenosine + spermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.16 Rattus norvegicus
-
 male Donryu rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.16 intestine
-
 Rattus norvegicus
-
2.5.1.16 kidney
-
 Rattus norvegicus
-
2.5.1.16 liver
-
 Rattus norvegicus
-
2.5.1.16 spleen
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.16 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.16 S-adenosylmethioninamine + putrescine
-
 Rattus norvegicus 5'-S-methyl-5'-thioadenosine + spermidine
-
 ?