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Literature summary extracted from
- Induced fit, drug design, and dUTPase (2004), Structure, 12, 2-3.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | drug development | induced fit drug design | Trypanosoma cruzi |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 3.6.1.23 | enzyme in complex with inhibitor dUDP, crystal structure determination and analysis | Trypanosoma cruzi |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.23 | dUDP | binding structure | Trypanosoma cruzi |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.23 | Mg2+ | required | Trypanosoma cruzi | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O | Trypanosoma cruzi | the reaction produces the primary source of substrate for synthesis of dTTP and reduces the intracellular dUTP concentration, thus limiting the misincorporation of uracil into DNA | dUMP + diphosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.23 | Trypanosoma cruzi | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O = dUMP + diphosphate | structural and catalytic mechanism | Trypanosoma cruzi |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O | the reaction produces the primary source of substrate for synthesis of dTTP and reduces the intracellular dUTP concentration, thus limiting the misincorporation of uracil into DNA | Trypanosoma cruzi | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | substrate binding structure analysis, overview | Trypanosoma cruzi | dUMP + diphosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | dimer | cyrstal structure analysis, overview | Trypanosoma cruzi |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | dUTPase | - |
Trypanosoma cruzi |
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Release 2023.1 (January 2023)
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