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Literature summary extracted from

  • Ko, W.C.; Shih, C.M.; Lai, Y.H.; Chen, J.H.; Huang, H.L.
    Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships (2004), Biochem. Pharmacol., 68, 2087-2094.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 apigenin IC50: 0.0105 mM, PDB3; IC50: 0.0167 mM, PDB2; IC50: 0.0254 mM, PDB1 Cavia porcellus
3.1.4.17 Biochanin A IC50: 0.0279 mM, PDE2; IC50: 0.0291 mM, PDE1 Cavia porcellus
3.1.4.17 daidzein IC50: 0.0286 mM, PDE3 Cavia porcellus
3.1.4.17 diosmetin IC50: 0.0048 mM, PDB2; IC50: 0.0144 mM, PDB1 Cavia porcellus
3.1.4.17 eriodictyol IC50: 0.0525 mM, PDB3 Cavia porcellus
3.1.4.17 genistein IC50: 0.0017 mM, PDB2; IC50: 0.0129 mM, PDB3; IC50: 0.0168 mM, PDB1 Cavia porcellus
3.1.4.17 luteolin IC50: 0.0101 mM, PDB3; IC50: 0.0133 mM, PDB2; IC50: 0.0215 mM, PDB1 Cavia porcellus
3.1.4.17 luteolin-7-glucoside IC50: 0.0351 mM, PDB2 Cavia porcellus
3.1.4.17 myricetin IC50: 0.0124 mM, PDB3; IC50: 0.0128 mM, PDB2; IC50: 0.0249 mM, PDB1 Cavia porcellus
3.1.4.17 quercetin IC50: 0.0056 mM, PDB3; IC50: 0.0179 mM, PDB2; IC50: 0.0278 mM, PDB1 Cavia porcellus
3.1.4.35 diosmetin IC50: 0.015 mM, PDB5 Cavia porcellus
3.1.4.35 genistein IC50: 0.073 mM, PDB5 Cavia porcellus
3.1.4.35 luteolin IC50: 0.0193 mM, PDB5 Cavia porcellus
3.1.4.53 Biochanin A IC50: 0.0085 mM, more selectively inhibits PDE4 than PDE1 or PDE2 Cavia porcellus
3.1.4.53 diosmetin IC50: 0.0202 mM, PDE4 Cavia porcellus
3.1.4.53 genistein IC50: 0.0095 mM, PDE4 Cavia porcellus
3.1.4.53 hesperetin IC50: 0.0282 mM, PDE4 Cavia porcellus
3.1.4.53 luteolin IC50: 0.0191 mM, PDE4 Cavia porcellus
3.1.4.53 luteolin-7-glucoside IC50: 0.043 mM, PDB4, dual inhibition of PDE2 and PDE4 Cavia porcellus
3.1.4.53 myricetin IC50: 0.0389 mM, PDE4 Cavia porcellus
3.1.4.53 prunetin IC50: 0.0114 mM, PDE4 Cavia porcellus
3.1.4.53 quercetin IC50: 0.0099 mM, PDE4 Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Cavia porcellus
-
-
-
3.1.4.35 Cavia porcellus
-
-
-
3.1.4.53 Cavia porcellus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 PDB1
-
 Cavia porcellus
3.1.4.17 PDB2
-
 Cavia porcellus
3.1.4.17 PDB3
-
 Cavia porcellus
3.1.4.35 PDB5
-
 Cavia porcellus
3.1.4.53 PDE4
-
 Cavia porcellus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.17 0.0017
-
 IC50: 0.0017 mM, PDB2 Cavia porcellus genistein
3.1.4.17 0.0048
-
 IC50: 0.0048 mM, PDB2 Cavia porcellus diosmetin
3.1.4.17 0.0056
-
 IC50: 0.0056 mM, PDB3 Cavia porcellus quercetin
3.1.4.17 0.0101
-
 IC50: 0.0101 mM, PDB3 Cavia porcellus luteolin
3.1.4.17 0.0105
-
 IC50: 0.0105 mM, PDB3 Cavia porcellus apigenin
3.1.4.17 0.0124
-
 IC50: 0.0124 mM, PDB3 Cavia porcellus myricetin
3.1.4.17 0.0128
-
 IC50: 0.0128 mM, PDB2 Cavia porcellus myricetin
3.1.4.17 0.0129
-
 IC50: 0.0129 mM, PDB3 Cavia porcellus genistein
3.1.4.17 0.0133
-
 IC50: 0.0133 mM, PDB2 Cavia porcellus luteolin
3.1.4.17 0.0144
-
 IC50: 0.0144 mM, PDB1 Cavia porcellus diosmetin
3.1.4.17 0.0167
-
 IC50: 0.0167 mM, PDB2 Cavia porcellus apigenin
3.1.4.17 0.0168
-
 IC50: 0.0168 mM, PDB1 Cavia porcellus genistein
3.1.4.17 0.0179
-
 IC50: 0.0179 mM, PDB2 Cavia porcellus quercetin
3.1.4.17 0.0215
-
 IC50: 0.0215 mM, PDB1 Cavia porcellus luteolin
3.1.4.17 0.0249
-
 IC50: 0.0249 mM, PDB1 Cavia porcellus myricetin
3.1.4.17 0.0254
-
 IC50: 0.0254 mM, PDB1 Cavia porcellus apigenin
3.1.4.17 0.0278
-
 IC50: 0.0278 mM, PDB1 Cavia porcellus quercetin
3.1.4.17 0.0279
-
 IC50: 0.0279 mM, PDE2 Cavia porcellus Biochanin A
3.1.4.17 0.0286
-
 IC50: 0.0286 mM, PDE3 Cavia porcellus daidzein
3.1.4.17 0.0291
-
 IC50: 0.0291 mM, PDE1 Cavia porcellus Biochanin A
3.1.4.17 0.0351
-
 IC50: 0.0351 mM, PDB2 Cavia porcellus luteolin-7-glucoside
3.1.4.17 0.0525
-
 IC50: 0.0525 mM, PDB3 Cavia porcellus eriodictyol
3.1.4.35 0.015
-
 IC50: 0.015 mM, PDB5 Cavia porcellus diosmetin
3.1.4.35 0.0193
-
 IC50: 0.0193 mM, PDB5 Cavia porcellus luteolin
3.1.4.35 0.073
-
 IC50: 0.073 mM, PDB5 Cavia porcellus genistein
3.1.4.53 0.0085
-
 IC50: 0.0085 mM, more selectively inhibits PDE4 than PDE1 or PDE2 Cavia porcellus Biochanin A
3.1.4.53 0.0095
-
 IC50: 0.0095 mM, PDE4 Cavia porcellus genistein
3.1.4.53 0.0099
-
 IC50: 0.0099 mM, PDE4 Cavia porcellus quercetin
3.1.4.53 0.0114
-
 IC50: 0.0114 mM, PDE4 Cavia porcellus prunetin
3.1.4.53 0.0191
-
 IC50: 0.0191 mM, PDE4 Cavia porcellus luteolin
3.1.4.53 0.0202
-
 IC50: 0.0202 mM, PDE4 Cavia porcellus diosmetin
3.1.4.53 0.0282
-
 IC50: 0.0282 mM, PDE4 Cavia porcellus hesperetin
3.1.4.53 0.0389
-
 IC50: 0.0389 mM, PDE4 Cavia porcellus myricetin
3.1.4.53 0.043
-
 IC50: 0.043 mM, PDB4, dual inhibitionof PDE2 and PDE4 Cavia porcellus luteolin-7-glucoside