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Literature summary extracted from

  • Wadhwa, R.; Takano, S.; Kaur, K.; Aida, S.; Yaguchi, T.; Kaul, Z.; Hirano, T.; Taira, K.; Kaul, S.C.
    Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60 (2005), Biochem. J., 391, 185-190.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
7.4.2.3 medicine in vivo binding of mortalin/mtHsp70 with HSP60, involvment in tumorigenesis, functional distinction in pathways involved in senescence Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
7.4.2.3 additional information recombinant GST-tagged mortalin/mtHsp70 deletion mutants, which demonstrate binding of mortalin via its N-terminal region Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.4.10 mitochondrion
-
 Homo sapiens 5739
-
5.6.1.7 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.6.4.10 Homo sapiens
-
-
-
5.6.1.7 Homo sapiens
-
-
-
7.4.2.3 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.4.2.3
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.4.10 fibroblast overexpression of mortalin/mtHsp70 extends the in vitro lifespan of normal human fibroblasts Homo sapiens
-
3.6.4.10 osteosarcoma cell knock-down of mortalin/mtHsp70 causes their growth arrest Homo sapiens
-
5.6.1.7 fibroblast overexpression of Hsp60 does not extend the in vitro lifespan of normal human fibroblasts Homo sapiens
-
5.6.1.7 osteosarcoma cell knock-down of Hsp60 causes their growth arrest Homo sapiens
-
7.4.2.3 fibroblast TIG-1 cell, overexpression of mortalin extends the in vitro lifespan of the fibroblasts Homo sapiens
-
7.4.2.3 additional information NARF cell, stably transfected with isopropyl beta-D-thiogalactoside-inducible p14ARF Homo sapiens
-
7.4.2.3 osteosarcoma cell line
-
 Homo sapiens
-
7.4.2.3 U2-OS cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.6.4.10 mitochondrial hsp70
-
 Homo sapiens
3.6.4.10 mortalin/mtHsp70
-
 Homo sapiens
5.6.1.7 heat shock protein 60
-
 Homo sapiens
5.6.1.7 Hsp60
-
 Homo sapiens
7.4.2.3 mitochondrial hsp70
-
 Homo sapiens
7.4.2.3 mortalin/mtHsp70
-
 Homo sapiens