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Literature summary extracted from
- Modulation of human dUTPase using small interfering RNA (2005), Biochem. Biophys. Res. Commun., 327, 306-310.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | drug development | the enzyme might be a target for drug development | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.23 | siRNAdUT3 | a 21 base-pair double-stranded RNA molecule targeted against the motif 3 of the enzyme, time- and dose-dependent decrease in the dUTPase activity in transfected cells | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.6.1.23 | mitochondrion | - |
Homo sapiens | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.23 | Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O | Homo sapiens | - |
dUMP + diphosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.23 | Homo sapiens | P33316 | gene DUT; gene DUT | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.6.1.23 | HeLa cell | - |
Homo sapiens | - |
| 3.6.1.23 | HT-29 cell | - |
Homo sapiens | - |
| 3.6.1.23 | SW-620 cell | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.23 | additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O | - |
Homo sapiens | dUMP + diphosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Homo sapiens |
| 3.6.1.23 | deoxyuridine triphosphate nucleotidohydrolase | - |
Homo sapiens |
| 3.6.1.23 | dUTP pyrophosphatase | - |
Homo sapiens |
| 3.6.1.23 | dUTPase | - |
Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.23 | 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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