Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zheng, W.; Brandish, P.E.; Kolodin, D.G.; Scolnick, E.M.; Strulovici, B.
    High-throughput cell-based screening using scintillation proximity assay for the discovery of inositol phosphatase inhibitors (2004), J. Biomol. Screen., 9, 132-140.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.25 drug development the enzyme is a target for development of lithium-mimetic agents for the treatment of bipolar disorder, high-throughput cell-based screening using scintillation proximity assay for the discovery of enzyme inhibitors, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.25 L-690330 bisphosphonate enzyme inhibitor Homo sapiens
3.1.3.25 L-690488 a tetrapivaloyloxymethyl ester prodrug of L-690330 Homo sapiens
3.1.3.25 Li+
-
 Homo sapiens
3.1.3.25 additional information high-throughput cell-based screening using scintillation proximity assay measuring G-protein-coupled receptor activation for evaluation of inhibitory potency of lithium mimetics, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.25 additional information Homo sapiens the enzyme is involved in development of bipolar disorder ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.25 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.25 brain
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.25 additional information
-
 scintillation proximity assay development Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.25 D-myo-inositol 1-phosphate + H2O
-
 Homo sapiens D-myo-inositol + phosphate
-
 ?
3.1.3.25 additional information the enzyme is involved in development of bipolar disorder Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.25 IMPase
-
 Homo sapiens
3.1.3.25 inositol phosphatase
-
 Homo sapiens