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Literature summary extracted from

  • Maeda, I.; Delessert, S.; Hasegawa, S.; Seto, Y.; Zuber, S.; Poirier, Y.
    The peroxisomal acyl-CoA thioesterase Pte1p from Saccharomyces cerevisiae is required for efficient degradation of short straight chain and branched chain fatty acids (2006), J. Biol. Chem., 281, 11729-11735.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.20
-
 Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.20 CoASH IC50: 0.03 mM Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.2.20 0.0059
-
 oleoyl-CoA pH 8.0 Saccharomyces cerevisiae
3.1.2.20 0.0104
-
 dodecanoyl-CoA pH 8.0 Saccharomyces cerevisiae
3.1.2.20 0.0175
-
 octanoyl-CoA pH 8.0 Saccharomyces cerevisiae
3.1.2.20 0.019
-
 8-methylnonanoyl-CoA pH 8.0 Saccharomyces cerevisiae
3.1.2.20 0.0218
-
 nonanoyl-CoA pH 8.0 Saccharomyces cerevisiae
3.1.2.20 0.0271
-
 decanoyl-CoA pH 8.0 Saccharomyces cerevisiae
3.1.2.20 0.0352
-
 butanoyl-CoA pH 8.0 Saccharomyces cerevisiae
3.1.2.20 0.0764
-
 acetyl-CoA pH 8.0 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.20 peroxisome
-
 Saccharomyces cerevisiae 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.20 43400
-
 x * 43400, SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.20 8-methyl-nonanoyl-CoA + H2O Saccharomyces cerevisiae
-
 8-methylnonanoate + CoA
-
 ?
3.1.2.20 acetyl-CoA + H2O Saccharomyces cerevisiae
-
 acetate + CoA
-
 ?
3.1.2.20 acyl-CoA + H2O Saccharomyces cerevisiae the enzyme is required for efficient degradation of short straight chain and branched chain fatty acids CoA + a carboxylate
-
 ?
3.1.2.20 butanoyl-CoA + H2O Saccharomyces cerevisiae highest specific activity of the substrates tested butanoate + CoA
-
 ?
3.1.2.20 decanoyl-CoA + H2O Saccharomyces cerevisiae
-
 decanoate + CoA
-
 ?
3.1.2.20 dodecanoyl-CoA + H2O Saccharomyces cerevisiae
-
 dodecanoate + CoA
-
 ?
3.1.2.20 nonanoyl-CoA + H2O Saccharomyces cerevisiae
-
 nonanoate + CoA
-
 ?
3.1.2.20 octanoyl-CoA + H2O Saccharomyces cerevisiae
-
 octanoate + CoA
-
 ?
3.1.2.20 oleoyl-CoA + H2O Saccharomyces cerevisiae
-
 oleate + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.20 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.2.20 recombinant Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.20 8-methyl-nonanoyl-CoA + H2O
-
 Saccharomyces cerevisiae 8-methylnonanoate + CoA
-
 ?
3.1.2.20 acetyl-CoA + H2O
-
 Saccharomyces cerevisiae acetate + CoA
-
 ?
3.1.2.20 acyl-CoA + H2O the enzyme is required for efficient degradation of short straight chain and branched chain fatty acids Saccharomyces cerevisiae CoA + a carboxylate
-
 ?
3.1.2.20 butanoyl-CoA + H2O highest specific activity of the substrates tested Saccharomyces cerevisiae butanoate + CoA
-
 ?
3.1.2.20 decanoyl-CoA + H2O
-
 Saccharomyces cerevisiae decanoate + CoA
-
 ?
3.1.2.20 dodecanoyl-CoA + H2O
-
 Saccharomyces cerevisiae dodecanoate + CoA
-
 ?
3.1.2.20 nonanoyl-CoA + H2O
-
 Saccharomyces cerevisiae nonanoate + CoA
-
 ?
3.1.2.20 octanoyl-CoA + H2O
-
 Saccharomyces cerevisiae octanoate + CoA
-
 ?
3.1.2.20 oleoyl-CoA + H2O
-
 Saccharomyces cerevisiae oleate + CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.2.20 ? x * 43400, SDS-PAGE Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
3.1.2.20 Pte1p
-
 Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.20 8
-
 activity with octanoyl-CoA Saccharomyces cerevisiae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.2.20 7 8.3 pH 7.0: about 30% of maximal activity, pH 8.3: about 65% of maximal activity, activity with octanoyl-CoA Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.2.20 0.03
-
 IC50: 0.03 mM Saccharomyces cerevisiae CoASH