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Literature summary extracted from

  • Samari, H.R.; Moeller, M.T.N.; Holden, L.; Asmyhr, T.; Seglen, P.O.
    Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophygy-suppressive toxins (2005), Biochem. J., 386, 237-244.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 5-aminoimidazole-4-carboxamide riboside stimulation of activating AMPK phosphorylation at Thr172 Rattus norvegicus
2.7.11.31 calyculin A stimulation of activating AMPK phosphorylation at Thr172, independent of narigin Rattus norvegicus
2.7.11.31 cantharidin stimulation of activating AMPK phosphorylation at Thr172, independent of narigin Rattus norvegicus
2.7.11.31 microcystin-LR stimulation of activating AMPK phosphorylation at Thr172 Rattus norvegicus
2.7.11.31 additional information stimulation by protein phosphatase-inhibitory toxins Rattus norvegicus
2.7.11.31 okadaic acid stimulation of activating AMPK phosphorylation at Thr172, activation is antagonized by naringin Rattus norvegicus
2.7.11.31 tautomycin stimulation of activating AMPK phosphorylation at Thr172, independent of narigin Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.31 naringin inhibits enzyme phosphorylation Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.31 additional information Rattus norvegicus AMPK regulation, AMPK mediates the autophagy suppression of okadaic acid and other protein phosphatase-inhibitory toxins, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.31 phosphoprotein the enzyme is activated by phosphorylation at Thr172, which is inhibited by naringin Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.31 hepatocyte
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.31 additional information
-
 autophagic activity under different conditions Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.31 ATP + acetyl-CoA carboxylase phosphorylation at Ser79 Rattus norvegicus ADP + phosphorylated acetyl-CoA carboxylase
-
 ?
2.7.11.31 additional information AMPK regulation, AMPK mediates the autophagy suppression of okadaic acid and other protein phosphatase-inhibitory toxins, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.31 AMP-activated protein kinase
-
 Rattus norvegicus
2.7.11.31 AMPK
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.31 ATP
-
 Rattus norvegicus