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Literature summary extracted from

  • Goenrich, M.; Mahlert, F.; Duin, E.C.; Bauer, C.; Jaun, B.; Thauer, R.K.
    Probing the reactivity of Ni in the active site of methyl-coenzyme M reductase with substrate analogues (2004), J. Biol. Inorg. Chem., 9, 691-705.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.4.1 2-bromoethanesulfonate reversible Methanothermobacter marburgensis
2.8.4.1 3-bromopropane sulfonate
-
 Methanothermobacter marburgensis
2.8.4.1 3-Bromopropionate irreversible Methanothermobacter marburgensis
2.8.4.1 3-iodopropane sulfonate
-
 Methanothermobacter marburgensis
2.8.4.1 4-bromobutyrate
-
 Methanothermobacter marburgensis
2.8.4.1 allyl-coenzyme M reversible Methanothermobacter marburgensis
2.8.4.1 cyano-coenzyme M irreversible Methanothermobacter marburgensis
2.8.4.1 propyl-coenzyme M reversible Methanothermobacter marburgensis
2.8.4.1 seleno-coenzyme M irreversible Methanothermobacter marburgensis
2.8.4.1 trifluoromethyl coenzyme M irreversible Methanothermobacter marburgensis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.4.1 5
-
 methyl coenzyme M
-
 Methanothermobacter marburgensis
2.8.4.1 20
-
 ethyl coenzyme M
-
 Methanothermobacter marburgensis

Organism

EC Number Organism UniProt Comment Textmining
2.8.4.1 Methanothermobacter marburgensis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.4.1
-
 Methanothermobacter marburgensis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.4.1 ethyl coenzyme M + coenzyme B 1% of the activity with methyl coenzyme M Methanothermobacter marburgensis ethane + CoM-S-S-CoB
-
 ?
2.8.4.1 methyl coenzyme M + coenzyme B
-
 Methanothermobacter marburgensis methane + CoM-S-S-CoB
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.4.1 methyl-coenzyme M reductase
-
 Methanothermobacter marburgensis

Cofactor

EC Number Cofactor Comment Organism Structure
2.8.4.1 F-430 prosthetic group has to be in the Ni(I) oxidation state for the enzyme to be active Methanothermobacter marburgensis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.8.4.1 0.1
-
 2-bromoethanesulfonate
-
 Methanothermobacter marburgensis
2.8.4.1 2
-
 allyl-coenzyme M
-
 Methanothermobacter marburgensis
2.8.4.1 5
-
 propyl-coenzyme M
-
 Methanothermobacter marburgensis