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Literature summary extracted from

  • Seeds, A.M.; Bastidas, R.J.; York, J.D.
    Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae (2005), J. Biol. Chem., 280, 27654-27661.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.151 genetic map of inositol metabolism, overexpression of isozyme Kcs1 can complement isozyme Ipk2 deficiency Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.151 additional information growth of an enzyme-deficient strain can be rescued by expression of either 1D-myo-inositol 1,4,5-trisphosphate 3-kinase or 6-kinase at high temperatures, but only 1D-myo-inositol 1,4,5-trisphosphate 6-kinase expression enables the strain to grow on ornithine Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.151 Mg2+
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.151 ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate Saccharomyces cerevisiae isozyme Kcs1 ADP + diphosphoinositol pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate Saccharomyces cerevisiae isozyme Kcs1 ADP + diphosphoinositol tetrakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate Saccharomyces cerevisiae preferred substrate of isozyme Ipk2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate Saccharomyces cerevisiae the enzyme initiates a inositol polyphosphate pathway, isozyme Kcs1 is also involved, inositol metabolism, overview ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate Saccharomyces cerevisiae preferred substrate of isozyme Ipk2 ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.151 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.151 ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate isozyme Kcs1 Saccharomyces cerevisiae ADP + diphosphoinositol pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate isozyme Kcs1 Saccharomyces cerevisiae ADP + diphosphoinositol tetrakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate preferred substrate of isozyme Ipk2 Saccharomyces cerevisiae ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate the enzyme initiates a inositol polyphosphate pathway, isozyme Kcs1 is also involved, inositol metabolism, overview Saccharomyces cerevisiae ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate isozyme Ipk2 and isozyme Kcs1 Saccharomyces cerevisiae ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate preferred substrate of isozyme Ipk2 Saccharomyces cerevisiae ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.151 Arg82
-
 Saccharomyces cerevisiae
2.7.1.151 inositol 1,4,5-trisphosphate 3-kinase
-
 Saccharomyces cerevisiae
2.7.1.151 inositol polyphosphate multikinase
-
 Saccharomyces cerevisiae
2.7.1.151 Ipk2
-
 Saccharomyces cerevisiae
2.7.1.151 Kcs1
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.151 37
-
 assay at Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.151 7.5
-
 assay at Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.151 ATP
-
 Saccharomyces cerevisiae