EC Number | Cloned (Comment) | Organism |
---|---|---|
5.6.2.1 | - |
Thermotoga maritima |
EC Number | General Stability | Organism |
---|---|---|
5.6.2.1 | topoisomerase I exhibits a unique hot spot susceptible to proteolytic attack with a variety of proteases (around amino acids 326-330). A truncated version of the enzyme lacking the C-terminal 93 amino acids is more susceptible to proteolysis, which suggests that the C-terminal region of the topoisomerase may be important to maintain the compact folding of the enzyme. Trypsin-digested topoisomerase I retains full DNA binding, cleavage and relaxation activities and full thermostability | Thermotoga maritima |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.6.2.1 | Thermotoga maritima | - |
- |
- |