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Literature summary extracted from

  • Nelson, S.W.; Binkowski, D.J.; Honzatko, R.B.; Fromm, H.J.
    Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase (2005), Biochemistry, 44, 766-774.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.6 expression in Escherichia coli Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.6 adenosine 5'-(beta,gamma-imido)triphosphate
-
 Escherichia coli
6.3.2.6 IMP competitive with respect to 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
6.3.2.6 Maleate competitive with respect to L-Asp Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.6 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.2.6
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.6 ATP + 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole + L-Asp rapid equilibrium random ter-ter mechanism Escherichia coli ADP + phosphate + 1-(5'-phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.6 Phosphoribosylaminoimidazolesuccinocarboxamide synthetase
-
 Escherichia coli
6.3.2.6 SAICAR synthetase
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.3.2.6 0.26
-
 adenosine 5'-(beta,gamma-imido)triphosphate 37°C, Kis, competitive versus ATP Escherichia coli
6.3.2.6 0.6
-
 adenosine 5'-(beta,gamma-imido)triphosphate 37°C, Kii, noncompetitive versus L-Asp Escherichia coli
6.3.2.6 0.6
-
 adenosine 5'-(beta,gamma-imido)triphosphate 37°C, Kis, noncompetitive versus 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
6.3.2.6 0.7
-
 adenosine 5'-(beta,gamma-imido)triphosphate 37°C, Kis, noncompetitive versus L-Asp Escherichia coli
6.3.2.6 4
-
 adenosine 5'-(beta,gamma-imido)triphosphate 37°C, Kii, noncompetitive versus 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
6.3.2.6 7
-
 IMP 37°C, Kis, noncompetitive versus ATP Escherichia coli
6.3.2.6 7
-
 IMP 37°C, Kis, noncompetitive versus L-Asp Escherichia coli
6.3.2.6 9
-
 IMP 37°C, Kii, noncompetitive versus ATP Escherichia coli
6.3.2.6 9.1
-
 IMP 37°C, Kis, competitive versus 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
6.3.2.6 12
-
 Maleate 37°C, Kis, noncompetitive versus ATP Escherichia coli
6.3.2.6 13
-
 IMP 37°C, Kii, noncompetitive versus L-Asp Escherichia coli
6.3.2.6 15
-
 Maleate 37°C, Kis, competitive versus 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
6.3.2.6 16
-
 Maleate 37°C, Kis, competitive versus L-Asp Escherichia coli
6.3.2.6 40
-
 Maleate 37°C, Kii, competitive versus 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
6.3.2.6 50
-
 Maleate 37°C, Kii, noncompetitive versus ATP Escherichia coli