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Literature summary extracted from

  • Sundaresan, V.; Chartron, J.; Yamaguchi, M.; Stout, C.D.
    Conformational diversity in NAD(H) and interacting transhydrogenase nicotinamide nucleotide binding domains (2005), J. Mol. Biol., 346, 617-629.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.1.1.1 domain dI and His-tag fusion protein of dIII separately expressed in Escherichia coli Rhodospirillum rubrum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
7.1.1.1 domain dIII, domain dI dimer and dI2dIII complex in the presence of limiting NADH using the vapor diffusion method Rhodospirillum rubrum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.1 membrane
-
 Rhodospirillum rubrum 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.1 NADH + NADP+ Rhodospirillum rubrum links hydride transfer between NAD(H) and NADP(H) to the outside in translocation of protons across membrane, provides NADPH for biosynthesis and reduction of glutathione, reaction is stereospecific between th 4A position of NAD(H) to the 4B position of NADP(H) NAD+ + NADPH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.1 Rhodospirillum rubrum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.1 NADH + NADP+
-
 Rhodospirillum rubrum NAD+ + NADPH
-
 r
7.1.1.1 NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the outside in translocation of protons across membrane, provides NADPH for biosynthesis and reduction of glutathione, reaction is stereospecific between th 4A position of NAD(H) to the 4B position of NADP(H) Rhodospirillum rubrum NAD+ + NADPH
-
 r

Subunits

EC Number Subunits Comment Organism
7.1.1.1 dimer isolated dI domains Rhodospirillum rubrum
7.1.1.1 trimer dI2dIII trimers formed in mixtures of recombinant dI and dIII domains Rhodospirillum rubrum

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.1 NAD(P)+
-
 Rhodospirillum rubrum
7.1.1.1 NAD(P)H
-
 Rhodospirillum rubrum