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Literature summary extracted from

  • Douthwaite, S.; Crain, P.F.; Liu, M.; Poehlsgaard, J.
    The tylosin-resistance methyltransferase RlmAII (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748 (2004), J. Mol. Biol., 337, 1073-1077.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.188 S-adenosyl-L-methionine + guanine748 in 23S rRNA Streptomyces fradiae the methyltransferase RlmAII (TlrB) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae. The resistance conferred by RlmAII is highly specific for tylosin, and no resistance is conferred to other macrolide drugs, or to lincosamide and streptogramin B drugs that bind to the same region on the bacterial ribosome S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
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Organism

EC Number Organism UniProt Comment Textmining
2.1.1.188 Streptomyces fradiae Q9S1M6
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.188 S-adenosyl-L-methionine + guanine748 in 23S rRNA the methyltransferase RlmAII (TlrB) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae. The resistance conferred by RlmAII is highly specific for tylosin, and no resistance is conferred to other macrolide drugs, or to lincosamide and streptogramin B drugs that bind to the same region on the bacterial ribosome Streptomyces fradiae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
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 ?
2.1.1.188 S-adenosyl-L-methionine + guanine748 in 23S rRNA the methylation site of RlmAII is identified by liquid chromatography/electrospray ionization mass spectrometry as the N-1 position of 23S rRNA nucleotide G748 Streptomyces fradiae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.188 RlmA(II)
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 Streptomyces fradiae
2.1.1.188 RlmAII
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 Streptomyces fradiae
2.1.1.188 TlrB
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 Streptomyces fradiae
2.1.1.188 tylosin-resistance methyltransferase RlmA(II)
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 Streptomyces fradiae